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C-reactive protein point of care testing in the management of acute respiratory infections in the Vietnamese primary healthcare setting – a cost benefit analysis

AIM: We assess the cost-benefit implications of C-reactive protein (CRP) testing in reducing antibiotic prescription for acute respiratory infection in Viet Nam by comparing the incremental costs of CRP testing with the economic costs of antimicrobial resistance averted due to lower antibiotic presc...

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Autores principales: Lubell, Yoel, Do, Nga T. T., Nguyen, Kinh V., Ta, Ngan T. D., Tran, Ninh T. H., Than, Hung M., Hoang, Long B., Shrestha, Poojan, van Doorn, Rogier H., Nadjm, Behzad, Wertheim, Heiman F. L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6172744/
https://www.ncbi.nlm.nih.gov/pubmed/30323922
http://dx.doi.org/10.1186/s13756-018-0414-1
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author Lubell, Yoel
Do, Nga T. T.
Nguyen, Kinh V.
Ta, Ngan T. D.
Tran, Ninh T. H.
Than, Hung M.
Hoang, Long B.
Shrestha, Poojan
van Doorn, Rogier H.
Nadjm, Behzad
Wertheim, Heiman F. L.
author_facet Lubell, Yoel
Do, Nga T. T.
Nguyen, Kinh V.
Ta, Ngan T. D.
Tran, Ninh T. H.
Than, Hung M.
Hoang, Long B.
Shrestha, Poojan
van Doorn, Rogier H.
Nadjm, Behzad
Wertheim, Heiman F. L.
author_sort Lubell, Yoel
collection PubMed
description AIM: We assess the cost-benefit implications of C-reactive protein (CRP) testing in reducing antibiotic prescription for acute respiratory infection in Viet Nam by comparing the incremental costs of CRP testing with the economic costs of antimicrobial resistance averted due to lower antibiotic prescribing. FINDINGS: Patients in the CRP group and the controls incurred similar costs in managing their illness, excluding the costs of the quantitative CRP tests, provided free of charge in the trial context. Assuming a unit cost of $1 per test, the incremental cost of CRP testing was $0.93 per patient. Based on a previous modelling analysis, the 20 percentage point reduction in prescribing observed in the trial implies a societal benefit of $0.82 per patient. With the low levels of adherence to the test results observed in the trial, CRP testing would not be cost-beneficial. The sensitivity analyses showed, however, that with higher adherence to test results their use would be cost-beneficial. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s13756-018-0414-1) contains supplementary material, which is available to authorized users.
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spelling pubmed-61727442018-10-15 C-reactive protein point of care testing in the management of acute respiratory infections in the Vietnamese primary healthcare setting – a cost benefit analysis Lubell, Yoel Do, Nga T. T. Nguyen, Kinh V. Ta, Ngan T. D. Tran, Ninh T. H. Than, Hung M. Hoang, Long B. Shrestha, Poojan van Doorn, Rogier H. Nadjm, Behzad Wertheim, Heiman F. L. Antimicrob Resist Infect Control Short Report AIM: We assess the cost-benefit implications of C-reactive protein (CRP) testing in reducing antibiotic prescription for acute respiratory infection in Viet Nam by comparing the incremental costs of CRP testing with the economic costs of antimicrobial resistance averted due to lower antibiotic prescribing. FINDINGS: Patients in the CRP group and the controls incurred similar costs in managing their illness, excluding the costs of the quantitative CRP tests, provided free of charge in the trial context. Assuming a unit cost of $1 per test, the incremental cost of CRP testing was $0.93 per patient. Based on a previous modelling analysis, the 20 percentage point reduction in prescribing observed in the trial implies a societal benefit of $0.82 per patient. With the low levels of adherence to the test results observed in the trial, CRP testing would not be cost-beneficial. The sensitivity analyses showed, however, that with higher adherence to test results their use would be cost-beneficial. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s13756-018-0414-1) contains supplementary material, which is available to authorized users. BioMed Central 2018-10-04 /pmc/articles/PMC6172744/ /pubmed/30323922 http://dx.doi.org/10.1186/s13756-018-0414-1 Text en © The Author(s). 2018 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Short Report
Lubell, Yoel
Do, Nga T. T.
Nguyen, Kinh V.
Ta, Ngan T. D.
Tran, Ninh T. H.
Than, Hung M.
Hoang, Long B.
Shrestha, Poojan
van Doorn, Rogier H.
Nadjm, Behzad
Wertheim, Heiman F. L.
C-reactive protein point of care testing in the management of acute respiratory infections in the Vietnamese primary healthcare setting – a cost benefit analysis
title C-reactive protein point of care testing in the management of acute respiratory infections in the Vietnamese primary healthcare setting – a cost benefit analysis
title_full C-reactive protein point of care testing in the management of acute respiratory infections in the Vietnamese primary healthcare setting – a cost benefit analysis
title_fullStr C-reactive protein point of care testing in the management of acute respiratory infections in the Vietnamese primary healthcare setting – a cost benefit analysis
title_full_unstemmed C-reactive protein point of care testing in the management of acute respiratory infections in the Vietnamese primary healthcare setting – a cost benefit analysis
title_short C-reactive protein point of care testing in the management of acute respiratory infections in the Vietnamese primary healthcare setting – a cost benefit analysis
title_sort c-reactive protein point of care testing in the management of acute respiratory infections in the vietnamese primary healthcare setting – a cost benefit analysis
topic Short Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6172744/
https://www.ncbi.nlm.nih.gov/pubmed/30323922
http://dx.doi.org/10.1186/s13756-018-0414-1
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