Time to death and risk factors among tuberculosis patients in Northern Ethiopia

OBJECTIVE: The main objective of this study was to assess time to death and associated risk factors among tuberculosis (TB) patients. RESULTS: A total of 769 TB patients were studied and of those, 87 (11.3%) patients died. All of the deaths occurred within 7 months of anti-tuberculosis therapy. Extr...

Descripción completa

Detalles Bibliográficos
Autores principales: Asgedom, Solomon Weldegebreal, Tesfaye, Daniel, Nirayo, Yirga Legesse, Atey, Tesfay Mehari
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research Note
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6172746/
https://www.ncbi.nlm.nih.gov/pubmed/30286801
http://dx.doi.org/10.1186/s13104-018-3806-7
_version_ 1783361000858189824
author Asgedom, Solomon Weldegebreal
Tesfaye, Daniel
Nirayo, Yirga Legesse
Atey, Tesfay Mehari
author_facet Asgedom, Solomon Weldegebreal
Tesfaye, Daniel
Nirayo, Yirga Legesse
Atey, Tesfay Mehari
author_sort Asgedom, Solomon Weldegebreal
collection PubMed
description OBJECTIVE: The main objective of this study was to assess time to death and associated risk factors among tuberculosis (TB) patients. RESULTS: A total of 769 TB patients were studied and of those, 87 (11.3%) patients died. All of the deaths occurred within 7 months of anti-tuberculosis therapy. Extra-pulmonary TB (AHR = 17.376, 95% CI; 3.88–77.86, p < 0.001) as compared to pulmonary TB and cotrimoxazole prophylaxis therapy (CPT) (AHR = 0.15, 95% CI; 0.03–0.74, p = 0.02) were found to be the predictors of mortality. We noticed higher rates of mortality. Extra-pulmonary TB patients have high risk and TB-HIV co-infected patients who received CPT have low risk of death. Improving early diagnosis of extra-pulmonary TB and early CPT initiation of TB-HIV co-infected patients could minimize patient’s mortality. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s13104-018-3806-7) contains supplementary material, which is available to authorized users.
format Online
Article
Text
id pubmed-6172746
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-61727462018-10-15 Time to death and risk factors among tuberculosis patients in Northern Ethiopia Asgedom, Solomon Weldegebreal Tesfaye, Daniel Nirayo, Yirga Legesse Atey, Tesfay Mehari BMC Res Notes Research Note OBJECTIVE: The main objective of this study was to assess time to death and associated risk factors among tuberculosis (TB) patients. RESULTS: A total of 769 TB patients were studied and of those, 87 (11.3%) patients died. All of the deaths occurred within 7 months of anti-tuberculosis therapy. Extra-pulmonary TB (AHR = 17.376, 95% CI; 3.88–77.86, p < 0.001) as compared to pulmonary TB and cotrimoxazole prophylaxis therapy (CPT) (AHR = 0.15, 95% CI; 0.03–0.74, p = 0.02) were found to be the predictors of mortality. We noticed higher rates of mortality. Extra-pulmonary TB patients have high risk and TB-HIV co-infected patients who received CPT have low risk of death. Improving early diagnosis of extra-pulmonary TB and early CPT initiation of TB-HIV co-infected patients could minimize patient’s mortality. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s13104-018-3806-7) contains supplementary material, which is available to authorized users. BioMed Central 2018-10-04 /pmc/articles/PMC6172746/ /pubmed/30286801 http://dx.doi.org/10.1186/s13104-018-3806-7 Text en © The Author(s) 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Note
Asgedom, Solomon Weldegebreal
Tesfaye, Daniel
Nirayo, Yirga Legesse
Atey, Tesfay Mehari
Time to death and risk factors among tuberculosis patients in Northern Ethiopia
title Time to death and risk factors among tuberculosis patients in Northern Ethiopia
title_full Time to death and risk factors among tuberculosis patients in Northern Ethiopia
title_fullStr Time to death and risk factors among tuberculosis patients in Northern Ethiopia
title_full_unstemmed Time to death and risk factors among tuberculosis patients in Northern Ethiopia
title_short Time to death and risk factors among tuberculosis patients in Northern Ethiopia
title_sort time to death and risk factors among tuberculosis patients in northern ethiopia
topic Research Note
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6172746/
https://www.ncbi.nlm.nih.gov/pubmed/30286801
http://dx.doi.org/10.1186/s13104-018-3806-7
work_keys_str_mv AT asgedomsolomonweldegebreal timetodeathandriskfactorsamongtuberculosispatientsinnorthernethiopia
AT tesfayedaniel timetodeathandriskfactorsamongtuberculosispatientsinnorthernethiopia
AT nirayoyirgalegesse timetodeathandriskfactorsamongtuberculosispatientsinnorthernethiopia
AT ateytesfaymehari timetodeathandriskfactorsamongtuberculosispatientsinnorthernethiopia

Ejemplares similares