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Monte Carlo Simulation on the Imaging Contrast Enhancement in Nanoparticle-enhanced Radiotherapy
This study focused on the imaging in radiotherapy by finding the relationship between the imaging contrast ratio and appropriate gold, iodine, iron oxide, silver, and platinum nanoparticle concentrations; the relationship between the imaging contrast ratio and different beam energies for the differe...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6172862/ https://www.ncbi.nlm.nih.gov/pubmed/30305778 http://dx.doi.org/10.4103/jmp.JMP_141_17 |
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author | Albayedh, Ferdos Chow, James C. L. |
author_facet | Albayedh, Ferdos Chow, James C. L. |
author_sort | Albayedh, Ferdos |
collection | PubMed |
description | This study focused on the imaging in radiotherapy by finding the relationship between the imaging contrast ratio and appropriate gold, iodine, iron oxide, silver, and platinum nanoparticle concentrations; the relationship between the imaging contrast ratio and different beam energies for the different nanoparticle concentrations; the relationship between the contrast ratio and various beam energies for gold nanoparticles; and the relationship between the contrast ratio and different thicknesses of the incident layer of the phantom including variety of gold nanoparticles (GNPs) concentration. Monte Carlo simulation was used to model the gold, iodine, iron oxide, silver, and platinum nanoparticle concentration which were infused within a heterogeneous phantom (50 cm × 50 cm × 10.5 cm) choosing different concentrations (3, 7, 18, 30, and 40 mg), and beams (100, 120, 130, and 140 kVp) correspondingly that were delivered into the phantom. The results showed obvious connection between the high concentration and having a high imaging contrast ratio, low energy and a high contrast ratio, small thickness, and a high contrast ratio. The superior nanoparticle obtained was GNP, the better concentration was 40 mg, the better beam energy was 100 kVp, and the better thickness was 0.5 cm. It is concluded that our study successfully proved that medical imaging contrast could be improved by increasing the contrast ratio using GNP as the finest choice to accomplish this improvement considering a high concentration, low beam energy, and a small thickness. |
format | Online Article Text |
id | pubmed-6172862 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-61728622018-10-10 Monte Carlo Simulation on the Imaging Contrast Enhancement in Nanoparticle-enhanced Radiotherapy Albayedh, Ferdos Chow, James C. L. J Med Phys Technical Note This study focused on the imaging in radiotherapy by finding the relationship between the imaging contrast ratio and appropriate gold, iodine, iron oxide, silver, and platinum nanoparticle concentrations; the relationship between the imaging contrast ratio and different beam energies for the different nanoparticle concentrations; the relationship between the contrast ratio and various beam energies for gold nanoparticles; and the relationship between the contrast ratio and different thicknesses of the incident layer of the phantom including variety of gold nanoparticles (GNPs) concentration. Monte Carlo simulation was used to model the gold, iodine, iron oxide, silver, and platinum nanoparticle concentration which were infused within a heterogeneous phantom (50 cm × 50 cm × 10.5 cm) choosing different concentrations (3, 7, 18, 30, and 40 mg), and beams (100, 120, 130, and 140 kVp) correspondingly that were delivered into the phantom. The results showed obvious connection between the high concentration and having a high imaging contrast ratio, low energy and a high contrast ratio, small thickness, and a high contrast ratio. The superior nanoparticle obtained was GNP, the better concentration was 40 mg, the better beam energy was 100 kVp, and the better thickness was 0.5 cm. It is concluded that our study successfully proved that medical imaging contrast could be improved by increasing the contrast ratio using GNP as the finest choice to accomplish this improvement considering a high concentration, low beam energy, and a small thickness. Medknow Publications & Media Pvt Ltd 2018 /pmc/articles/PMC6172862/ /pubmed/30305778 http://dx.doi.org/10.4103/jmp.JMP_141_17 Text en Copyright: © 2018 Journal of Medical Physics http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms. |
spellingShingle | Technical Note Albayedh, Ferdos Chow, James C. L. Monte Carlo Simulation on the Imaging Contrast Enhancement in Nanoparticle-enhanced Radiotherapy |
title | Monte Carlo Simulation on the Imaging Contrast Enhancement in Nanoparticle-enhanced Radiotherapy |
title_full | Monte Carlo Simulation on the Imaging Contrast Enhancement in Nanoparticle-enhanced Radiotherapy |
title_fullStr | Monte Carlo Simulation on the Imaging Contrast Enhancement in Nanoparticle-enhanced Radiotherapy |
title_full_unstemmed | Monte Carlo Simulation on the Imaging Contrast Enhancement in Nanoparticle-enhanced Radiotherapy |
title_short | Monte Carlo Simulation on the Imaging Contrast Enhancement in Nanoparticle-enhanced Radiotherapy |
title_sort | monte carlo simulation on the imaging contrast enhancement in nanoparticle-enhanced radiotherapy |
topic | Technical Note |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6172862/ https://www.ncbi.nlm.nih.gov/pubmed/30305778 http://dx.doi.org/10.4103/jmp.JMP_141_17 |
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