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Construction of the Pentacyclic Core and Formal Total Synthesis of (rac)‐Renieramycin T

A formal total synthesis of the antitumor marine natural product (rac)‐renieramycin T, which possesses a characteristic ecteinascidin‐type A ring in the renieramycin–saframycin core skeleton, was elaborated. The key steps in the synthesis of (rac)‐renieramycin T are a modified Pictet–Spengler cycliz...

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Detalles Bibliográficos
Autores principales: Kimura, Shinya, Saito, Naoki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6173372/
https://www.ncbi.nlm.nih.gov/pubmed/30338201
http://dx.doi.org/10.1002/open.201800112