Identification of the novel deletion-type PML-RARA mutation associated with the retinoic acid resistance in acute promyelocytic leukemia

All-trans retinoic acid (ATRA) and arsenic trioxide (ATO) are essential for acute promyelocytic leukemia (APL) treatment. It has been reported that mutations in PML-RARA confer resistance to ATRA and ATO, and are associated with poor prognosis. Although most PML-RARA mutations were point mutations,...

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Detalles Bibliográficos
Autores principales: Hattori, Hikaru, Ishikawa, Yuichi, Kawashima, Naomi, Akashi, Akimi, Yamaguchi, Yohei, Harada, Yasuhiko, Hirano, Daiki, Adachi, Yoshiya, Miyao, Kotaro, Ushijima, Yoko, Terakura, Seitaro, Nishida, Tetsuya, Matsushita, Tadashi, Kiyoi, Hitoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6173414/
https://www.ncbi.nlm.nih.gov/pubmed/30289902
http://dx.doi.org/10.1371/journal.pone.0204850

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