Cu/Zn-superoxide dismutase forms fibrillar hydrogels in a pH-dependent manner via a water-rich extended intermediate state

Under certain conditions, amyloid-like fibrils can develop into three-dimensional networks and form hydrogels by a self-assembly process. When Cu/Zn superoxide dismutase (SOD1), an anti-oxidative enzyme, undergoes misfolding, fibrillar aggregates are formed, which are a hallmark of a certain form of...

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Detalles Bibliográficos
Autores principales: Fujiwara, Noriko, Wagatsuma, Michiru, Oba, Naoto, Yoshihara, Daisaku, Tokuda, Eiichi, Sakiyama, Haruhiko, Eguchi, Hironobu, Ichihashi, Motoko, Furukawa, Yoshiaki, Inoue, Tadashi, Suzuki, Keiichiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6173426/
https://www.ncbi.nlm.nih.gov/pubmed/30289953
http://dx.doi.org/10.1371/journal.pone.0205090

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