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Star-Graft Quarterpolymer-Based Polymersomes as Nanocarriers for Co-Delivery of Hydrophilic/Hydrophobic Chemotherapeutic Agents
[Image: see text] We report the fabrication of polymersomes, using as building blocks star-graft quarterpolymers, composed of hydrophobic polystyrene and pH-sensitive poly(2-vinylpyridine)-b-poly(acrylic acid) (P2VP-b-PAA) arms, emanated from a common nodule, enriched by thermosensitive poly(N-isopr...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical Society
2018
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6173558/ https://www.ncbi.nlm.nih.gov/pubmed/30320280 http://dx.doi.org/10.1021/acsomega.8b01437 |
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author | Iatridi, Zacharoula Angelopoulou, Athina Voulgari, Efstathia Avgoustakis, Konstantinos Tsitsilianis, Constantinos |
author_facet | Iatridi, Zacharoula Angelopoulou, Athina Voulgari, Efstathia Avgoustakis, Konstantinos Tsitsilianis, Constantinos |
author_sort | Iatridi, Zacharoula |
collection | PubMed |
description | [Image: see text] We report the fabrication of polymersomes, using as building blocks star-graft quarterpolymers, composed of hydrophobic polystyrene and pH-sensitive poly(2-vinylpyridine)-b-poly(acrylic acid) (P2VP-b-PAA) arms, emanated from a common nodule, enriched by thermosensitive poly(N-isopropylacrylamide) grafts covalently bonded on the PAA block-arms. These multicompartmental polymersomes were evaluated as nanocarriers for the encapsulation and controlled co-delivery of doxorubicin (hydrophilic) and paclitaxel (hydrophobic) chemotherapeutic agents. The polymersomes can load these drugs in different compartments and can efficiently be internalized in the human lung adenocarcinoma epithelial cells, delivering their cargo and inducing high cell apoptosis. The release kinetics of both anticancer agents was controlled differently by the environmental conditions (pH and temperature). Enhanced release was observed at the acidic pH 6.0 and under physiological temperature (37 °C). At the same total drug level, co-delivery of these drugs with the polymersomes caused enhanced cytotoxicity and induced significantly higher cell apoptosis in the cancer cell line compared to the polymersomes loaded with either of the two drugs. |
format | Online Article Text |
id | pubmed-6173558 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | American Chemical Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-61735582018-10-11 Star-Graft Quarterpolymer-Based Polymersomes as Nanocarriers for Co-Delivery of Hydrophilic/Hydrophobic Chemotherapeutic Agents Iatridi, Zacharoula Angelopoulou, Athina Voulgari, Efstathia Avgoustakis, Konstantinos Tsitsilianis, Constantinos ACS Omega [Image: see text] We report the fabrication of polymersomes, using as building blocks star-graft quarterpolymers, composed of hydrophobic polystyrene and pH-sensitive poly(2-vinylpyridine)-b-poly(acrylic acid) (P2VP-b-PAA) arms, emanated from a common nodule, enriched by thermosensitive poly(N-isopropylacrylamide) grafts covalently bonded on the PAA block-arms. These multicompartmental polymersomes were evaluated as nanocarriers for the encapsulation and controlled co-delivery of doxorubicin (hydrophilic) and paclitaxel (hydrophobic) chemotherapeutic agents. The polymersomes can load these drugs in different compartments and can efficiently be internalized in the human lung adenocarcinoma epithelial cells, delivering their cargo and inducing high cell apoptosis. The release kinetics of both anticancer agents was controlled differently by the environmental conditions (pH and temperature). Enhanced release was observed at the acidic pH 6.0 and under physiological temperature (37 °C). At the same total drug level, co-delivery of these drugs with the polymersomes caused enhanced cytotoxicity and induced significantly higher cell apoptosis in the cancer cell line compared to the polymersomes loaded with either of the two drugs. American Chemical Society 2018-09-25 /pmc/articles/PMC6173558/ /pubmed/30320280 http://dx.doi.org/10.1021/acsomega.8b01437 Text en Copyright © 2018 American Chemical Society This is an open access article published under an ACS AuthorChoice License (http://pubs.acs.org/page/policy/authorchoice_termsofuse.html) , which permits copying and redistribution of the article or any adaptations for non-commercial purposes. |
spellingShingle | Iatridi, Zacharoula Angelopoulou, Athina Voulgari, Efstathia Avgoustakis, Konstantinos Tsitsilianis, Constantinos Star-Graft Quarterpolymer-Based Polymersomes as Nanocarriers for Co-Delivery of Hydrophilic/Hydrophobic Chemotherapeutic Agents |
title | Star-Graft Quarterpolymer-Based Polymersomes as Nanocarriers
for Co-Delivery of Hydrophilic/Hydrophobic Chemotherapeutic Agents |
title_full | Star-Graft Quarterpolymer-Based Polymersomes as Nanocarriers
for Co-Delivery of Hydrophilic/Hydrophobic Chemotherapeutic Agents |
title_fullStr | Star-Graft Quarterpolymer-Based Polymersomes as Nanocarriers
for Co-Delivery of Hydrophilic/Hydrophobic Chemotherapeutic Agents |
title_full_unstemmed | Star-Graft Quarterpolymer-Based Polymersomes as Nanocarriers
for Co-Delivery of Hydrophilic/Hydrophobic Chemotherapeutic Agents |
title_short | Star-Graft Quarterpolymer-Based Polymersomes as Nanocarriers
for Co-Delivery of Hydrophilic/Hydrophobic Chemotherapeutic Agents |
title_sort | star-graft quarterpolymer-based polymersomes as nanocarriers
for co-delivery of hydrophilic/hydrophobic chemotherapeutic agents |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6173558/ https://www.ncbi.nlm.nih.gov/pubmed/30320280 http://dx.doi.org/10.1021/acsomega.8b01437 |
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