Development of Mobile Laboratory for Viral Hemorrhagic Fever Detection in Africa

BACKGROUND: A mobile laboratory transportable on commercial flights was developed to enable local response to viral hemorrhagic fever outbreaks. METHODS: The development progressed from use of mobile real-time reverse-transcription polymerase chain reaction to mobile real-time recombinase polymerase...

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Detalles Bibliográficos
Autores principales: Weidmann, Manfred, Faye, Ousmane, Faye, Oumar, Abd El Wahed, Ahmed, Patel, Pranav, Batejat, Christophe, Manugerra, Jean Claude, Adjami, Aimee, Niedrig, Matthias, Hufert, Frank T, Sall, Amadou A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Major Articles and Brief Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6173574/
https://www.ncbi.nlm.nih.gov/pubmed/29917112
http://dx.doi.org/10.1093/infdis/jiy362
Descripción
Sumario:BACKGROUND: A mobile laboratory transportable on commercial flights was developed to enable local response to viral hemorrhagic fever outbreaks. METHODS: The development progressed from use of mobile real-time reverse-transcription polymerase chain reaction to mobile real-time recombinase polymerase amplification. In this study, we describe various stages of the mobile laboratory development. RESULTS: A brief overview of mobile laboratory deployments, which culminated in the first on-site detection of Ebola virus disease (EVD) in March 2014, and their successful use in a campaign to roll back EVD cases in Conakry in the West Africa Ebola virus outbreak are described. CONCLUSIONS: The developed mobile laboratory successfully enabled local teams to perform rapid disgnostic testing for viral hemorrhagic fever.

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