Development of Mobile Laboratory for Viral Hemorrhagic Fever Detection in Africa

BACKGROUND: A mobile laboratory transportable on commercial flights was developed to enable local response to viral hemorrhagic fever outbreaks. METHODS: The development progressed from use of mobile real-time reverse-transcription polymerase chain reaction to mobile real-time recombinase polymerase...

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Autores principales: Weidmann, Manfred, Faye, Ousmane, Faye, Oumar, Abd El Wahed, Ahmed, Patel, Pranav, Batejat, Christophe, Manugerra, Jean Claude, Adjami, Aimee, Niedrig, Matthias, Hufert, Frank T, Sall, Amadou A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Major Articles and Brief Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6173574/
https://www.ncbi.nlm.nih.gov/pubmed/29917112
http://dx.doi.org/10.1093/infdis/jiy362
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author Weidmann, Manfred
Faye, Ousmane
Faye, Oumar
Abd El Wahed, Ahmed
Patel, Pranav
Batejat, Christophe
Manugerra, Jean Claude
Adjami, Aimee
Niedrig, Matthias
Hufert, Frank T
Sall, Amadou A
author_facet Weidmann, Manfred
Faye, Ousmane
Faye, Oumar
Abd El Wahed, Ahmed
Patel, Pranav
Batejat, Christophe
Manugerra, Jean Claude
Adjami, Aimee
Niedrig, Matthias
Hufert, Frank T
Sall, Amadou A
author_sort Weidmann, Manfred
collection PubMed
description BACKGROUND: A mobile laboratory transportable on commercial flights was developed to enable local response to viral hemorrhagic fever outbreaks. METHODS: The development progressed from use of mobile real-time reverse-transcription polymerase chain reaction to mobile real-time recombinase polymerase amplification. In this study, we describe various stages of the mobile laboratory development. RESULTS: A brief overview of mobile laboratory deployments, which culminated in the first on-site detection of Ebola virus disease (EVD) in March 2014, and their successful use in a campaign to roll back EVD cases in Conakry in the West Africa Ebola virus outbreak are described. CONCLUSIONS: The developed mobile laboratory successfully enabled local teams to perform rapid disgnostic testing for viral hemorrhagic fever.
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spelling pubmed-61735742018-10-11 Development of Mobile Laboratory for Viral Hemorrhagic Fever Detection in Africa Weidmann, Manfred Faye, Ousmane Faye, Oumar Abd El Wahed, Ahmed Patel, Pranav Batejat, Christophe Manugerra, Jean Claude Adjami, Aimee Niedrig, Matthias Hufert, Frank T Sall, Amadou A J Infect Dis Major Articles and Brief Reports BACKGROUND: A mobile laboratory transportable on commercial flights was developed to enable local response to viral hemorrhagic fever outbreaks. METHODS: The development progressed from use of mobile real-time reverse-transcription polymerase chain reaction to mobile real-time recombinase polymerase amplification. In this study, we describe various stages of the mobile laboratory development. RESULTS: A brief overview of mobile laboratory deployments, which culminated in the first on-site detection of Ebola virus disease (EVD) in March 2014, and their successful use in a campaign to roll back EVD cases in Conakry in the West Africa Ebola virus outbreak are described. CONCLUSIONS: The developed mobile laboratory successfully enabled local teams to perform rapid disgnostic testing for viral hemorrhagic fever. Oxford University Press 2018-11-15 2018-06-15 /pmc/articles/PMC6173574/ /pubmed/29917112 http://dx.doi.org/10.1093/infdis/jiy362 Text en © The Author(s) 2018. Published by Oxford University Press for the Infectious Diseases Society of America. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Major Articles and Brief Reports
Weidmann, Manfred
Faye, Ousmane
Faye, Oumar
Abd El Wahed, Ahmed
Patel, Pranav
Batejat, Christophe
Manugerra, Jean Claude
Adjami, Aimee
Niedrig, Matthias
Hufert, Frank T
Sall, Amadou A
Development of Mobile Laboratory for Viral Hemorrhagic Fever Detection in Africa
title Development of Mobile Laboratory for Viral Hemorrhagic Fever Detection in Africa
title_full Development of Mobile Laboratory for Viral Hemorrhagic Fever Detection in Africa
title_fullStr Development of Mobile Laboratory for Viral Hemorrhagic Fever Detection in Africa
title_full_unstemmed Development of Mobile Laboratory for Viral Hemorrhagic Fever Detection in Africa
title_short Development of Mobile Laboratory for Viral Hemorrhagic Fever Detection in Africa
title_sort development of mobile laboratory for viral hemorrhagic fever detection in africa
topic Major Articles and Brief Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6173574/
https://www.ncbi.nlm.nih.gov/pubmed/29917112
http://dx.doi.org/10.1093/infdis/jiy362
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