Myelo-lymphoid lineage restriction occurs in the human haematopoietic stem cell compartment before lymphoid-primed multipotent progenitors

Capturing where and how multipotency is lost is crucial to understand how blood formation is controlled. Blood lineage specification is currently thought to occur downstream of multipotent haematopoietic stem cells (HSC). Here we show that, in human, the first lineage restriction events occur within...

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Detalles Bibliográficos
Autores principales: Belluschi, Serena, Calderbank, Emily F., Ciaurro, Valerio, Pijuan-Sala, Blanca, Santoro, Antonella, Mende, Nicole, Diamanti, Evangelia, Sham, Kendig Yen Chi, Wang, Xiaonan, Lau, Winnie W. Y., Jawaid, Wajid, Göttgens, Berthold, Laurenti, Elisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6173731/
https://www.ncbi.nlm.nih.gov/pubmed/30291229
http://dx.doi.org/10.1038/s41467-018-06442-4

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