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Brief Report: Potent clinical and radiological response to larotrectinib in TRK fusion-driven high-grade glioma
Genes encoding TRK are oncogenic drivers in multiple tumour types including infantile fibrosarcoma, papillary thyroid cancer and high-grade gliomas (HGG). TRK fusions have a critical role in tumourigenesis in 40% of infant HGG. Here we report the first case of a TRK fusion-driven HGG treated with la...
| Autores principales: | , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6173734/ https://www.ncbi.nlm.nih.gov/pubmed/30220707 http://dx.doi.org/10.1038/s41416-018-0251-2 |
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| author | Ziegler, David S. Wong, Marie Mayoh, Chelsea Kumar, Amit Tsoli, Maria Mould, Emily Tyrrell, Vanessa Khuong-Quang, Dong-Anh Pinese, Mark Gayevskiy, Velimir Cohn, Richard J. Lau, Loretta M. S. Reynolds, Mark Cox, Michael C. Gifford, Andrew Rodriguez, Michael Cowley, Mark J. Ekert, Paul G. Marshall, Glenn M. Haber, Michelle |
| author_facet | Ziegler, David S. Wong, Marie Mayoh, Chelsea Kumar, Amit Tsoli, Maria Mould, Emily Tyrrell, Vanessa Khuong-Quang, Dong-Anh Pinese, Mark Gayevskiy, Velimir Cohn, Richard J. Lau, Loretta M. S. Reynolds, Mark Cox, Michael C. Gifford, Andrew Rodriguez, Michael Cowley, Mark J. Ekert, Paul G. Marshall, Glenn M. Haber, Michelle |
| author_sort | Ziegler, David S. |
| collection | PubMed |
| description | Genes encoding TRK are oncogenic drivers in multiple tumour types including infantile fibrosarcoma, papillary thyroid cancer and high-grade gliomas (HGG). TRK fusions have a critical role in tumourigenesis in 40% of infant HGG. Here we report the first case of a TRK fusion-driven HGG treated with larotrectinib—the first selective pan-TRK inhibitor in clinical development. This 3-year-old girl had failed multiple therapies including chemotherapy and radiotherapy. Tumour profiling confirmed an ETV6–NTRK3 fusion. Treatment with larotrectinib led to rapid clinical improvement with near total resolution of primary and metastatic lesions on MRI imaging. This is the first report of a TRK fusion glioma successfully treated with a TRK inhibitor. |
| format | Online Article Text |
| id | pubmed-6173734 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2018 |
| publisher | Nature Publishing Group UK |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-61737342019-09-04 Brief Report: Potent clinical and radiological response to larotrectinib in TRK fusion-driven high-grade glioma Ziegler, David S. Wong, Marie Mayoh, Chelsea Kumar, Amit Tsoli, Maria Mould, Emily Tyrrell, Vanessa Khuong-Quang, Dong-Anh Pinese, Mark Gayevskiy, Velimir Cohn, Richard J. Lau, Loretta M. S. Reynolds, Mark Cox, Michael C. Gifford, Andrew Rodriguez, Michael Cowley, Mark J. Ekert, Paul G. Marshall, Glenn M. Haber, Michelle Br J Cancer Brief Communication Genes encoding TRK are oncogenic drivers in multiple tumour types including infantile fibrosarcoma, papillary thyroid cancer and high-grade gliomas (HGG). TRK fusions have a critical role in tumourigenesis in 40% of infant HGG. Here we report the first case of a TRK fusion-driven HGG treated with larotrectinib—the first selective pan-TRK inhibitor in clinical development. This 3-year-old girl had failed multiple therapies including chemotherapy and radiotherapy. Tumour profiling confirmed an ETV6–NTRK3 fusion. Treatment with larotrectinib led to rapid clinical improvement with near total resolution of primary and metastatic lesions on MRI imaging. This is the first report of a TRK fusion glioma successfully treated with a TRK inhibitor. Nature Publishing Group UK 2018-09-17 2018-09-11 /pmc/articles/PMC6173734/ /pubmed/30220707 http://dx.doi.org/10.1038/s41416-018-0251-2 Text en © The Author(s) 2018 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
| spellingShingle | Brief Communication Ziegler, David S. Wong, Marie Mayoh, Chelsea Kumar, Amit Tsoli, Maria Mould, Emily Tyrrell, Vanessa Khuong-Quang, Dong-Anh Pinese, Mark Gayevskiy, Velimir Cohn, Richard J. Lau, Loretta M. S. Reynolds, Mark Cox, Michael C. Gifford, Andrew Rodriguez, Michael Cowley, Mark J. Ekert, Paul G. Marshall, Glenn M. Haber, Michelle Brief Report: Potent clinical and radiological response to larotrectinib in TRK fusion-driven high-grade glioma |
| title | Brief Report: Potent clinical and radiological response to larotrectinib in TRK fusion-driven high-grade glioma |
| title_full | Brief Report: Potent clinical and radiological response to larotrectinib in TRK fusion-driven high-grade glioma |
| title_fullStr | Brief Report: Potent clinical and radiological response to larotrectinib in TRK fusion-driven high-grade glioma |
| title_full_unstemmed | Brief Report: Potent clinical and radiological response to larotrectinib in TRK fusion-driven high-grade glioma |
| title_short | Brief Report: Potent clinical and radiological response to larotrectinib in TRK fusion-driven high-grade glioma |
| title_sort | brief report: potent clinical and radiological response to larotrectinib in trk fusion-driven high-grade glioma |
| topic | Brief Communication |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6173734/ https://www.ncbi.nlm.nih.gov/pubmed/30220707 http://dx.doi.org/10.1038/s41416-018-0251-2 |
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