Brief Report: Potent clinical and radiological response to larotrectinib in TRK fusion-driven high-grade glioma

Genes encoding TRK are oncogenic drivers in multiple tumour types including infantile fibrosarcoma, papillary thyroid cancer and high-grade gliomas (HGG). TRK fusions have a critical role in tumourigenesis in 40% of infant HGG. Here we report the first case of a TRK fusion-driven HGG treated with la...

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Detalles Bibliográficos
Autores principales: Ziegler, David S., Wong, Marie, Mayoh, Chelsea, Kumar, Amit, Tsoli, Maria, Mould, Emily, Tyrrell, Vanessa, Khuong-Quang, Dong-Anh, Pinese, Mark, Gayevskiy, Velimir, Cohn, Richard J., Lau, Loretta M. S., Reynolds, Mark, Cox, Michael C., Gifford, Andrew, Rodriguez, Michael, Cowley, Mark J., Ekert, Paul G., Marshall, Glenn M., Haber, Michelle
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6173734/
https://www.ncbi.nlm.nih.gov/pubmed/30220707
http://dx.doi.org/10.1038/s41416-018-0251-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6173734/
https://www.ncbi.nlm.nih.gov/pubmed/30220707
http://dx.doi.org/10.1038/s41416-018-0251-2

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