Copy number load predicts outcome of metastatic colorectal cancer patients receiving bevacizumab combination therapy

Increased copy number alterations (CNAs) indicative of chromosomal instability (CIN) have been associated with poor cancer outcome. Here, we study CNAs as potential biomarkers of bevacizumab (BVZ) response in metastatic colorectal cancer (mCRC). We cluster 409 mCRCs in three subclusters characterize...

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Detalles Bibliográficos
Autores principales: Smeets, Dominiek, Miller, Ian S., O’Connor, Darran P., Das, Sudipto, Moran, Bruce, Boeckx, Bram, Gaiser, Timo, Betge, Johannes, Barat, Ana, Klinger, Rut, van Grieken, Nicole C. T., Cremolini, Chiara, Prenen, Hans, Mazzone, Massimiliano, Depreeuw, Jeroen, Bacon, Orna, Fender, Bozena, Brady, Joseph, Hennessy, Bryan T., McNamara, Deborah A., Kay, Elaine, Verheul, Henk M., Maarten, Neerincx, Gallagher, William M., Murphy, Verena, Prehn, Jochen H. M., Koopman, Miriam, Punt, Cornelis J. A., Loupakis, Fotios, Ebert, Matthias P. A., Ylstra, Bauke, Lambrechts, Diether, Byrne, Annette T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6173768/
https://www.ncbi.nlm.nih.gov/pubmed/30291241
http://dx.doi.org/10.1038/s41467-018-06567-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6173768/
https://www.ncbi.nlm.nih.gov/pubmed/30291241
http://dx.doi.org/10.1038/s41467-018-06567-6

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