Direct electrical quantification of glucose and asparagine from bodily fluids using nanopores

Crucial steps in the miniaturisation of biosensors are the conversion of a biological signal into an electrical current as well as the direct sampling of bodily fluids. Here we show that protein sensors in combination with a nanopore, acting as an electrical transducer, can accurately quantify metab...

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Detalles Bibliográficos
Autores principales: Galenkamp, Nicole Stéphanie, Soskine, Misha, Hermans, Jos, Wloka, Carsten, Maglia, Giovanni
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6173770/
https://www.ncbi.nlm.nih.gov/pubmed/30291230
http://dx.doi.org/10.1038/s41467-018-06534-1
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author Galenkamp, Nicole Stéphanie
Soskine, Misha
Hermans, Jos
Wloka, Carsten
Maglia, Giovanni
author_facet Galenkamp, Nicole Stéphanie
Soskine, Misha
Hermans, Jos
Wloka, Carsten
Maglia, Giovanni
author_sort Galenkamp, Nicole Stéphanie
collection PubMed
description Crucial steps in the miniaturisation of biosensors are the conversion of a biological signal into an electrical current as well as the direct sampling of bodily fluids. Here we show that protein sensors in combination with a nanopore, acting as an electrical transducer, can accurately quantify metabolites in real time directly from nanoliter amounts of blood and other bodily fluids. Incorporation of the nanopore into portable electronic devices will allow developing sensitive, continuous, and non-invasive sensors for metabolites for point-of-care and home diagnostics.
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spelling pubmed-61737702018-10-09 Direct electrical quantification of glucose and asparagine from bodily fluids using nanopores Galenkamp, Nicole Stéphanie Soskine, Misha Hermans, Jos Wloka, Carsten Maglia, Giovanni Nat Commun Article Crucial steps in the miniaturisation of biosensors are the conversion of a biological signal into an electrical current as well as the direct sampling of bodily fluids. Here we show that protein sensors in combination with a nanopore, acting as an electrical transducer, can accurately quantify metabolites in real time directly from nanoliter amounts of blood and other bodily fluids. Incorporation of the nanopore into portable electronic devices will allow developing sensitive, continuous, and non-invasive sensors for metabolites for point-of-care and home diagnostics. Nature Publishing Group UK 2018-10-05 /pmc/articles/PMC6173770/ /pubmed/30291230 http://dx.doi.org/10.1038/s41467-018-06534-1 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Galenkamp, Nicole Stéphanie
Soskine, Misha
Hermans, Jos
Wloka, Carsten
Maglia, Giovanni
Direct electrical quantification of glucose and asparagine from bodily fluids using nanopores
title Direct electrical quantification of glucose and asparagine from bodily fluids using nanopores
title_full Direct electrical quantification of glucose and asparagine from bodily fluids using nanopores
title_fullStr Direct electrical quantification of glucose and asparagine from bodily fluids using nanopores
title_full_unstemmed Direct electrical quantification of glucose and asparagine from bodily fluids using nanopores
title_short Direct electrical quantification of glucose and asparagine from bodily fluids using nanopores
title_sort direct electrical quantification of glucose and asparagine from bodily fluids using nanopores
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6173770/
https://www.ncbi.nlm.nih.gov/pubmed/30291230
http://dx.doi.org/10.1038/s41467-018-06534-1
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