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Targeted therapy for the post-operative conjunctiva: SPARC silencing reduces collagen deposition

BACKGROUND: To develop targeted antifibrotic therapy for glaucoma filtration surgery; this study determines the effectiveness of small interfering RNA (siRNA) to reduce in vivo secreted protein acidic and rich in cysteine (SPARC) expression using the mouse model of conjunctival scarring. METHODS: Ex...

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Detalles Bibliográficos
Autores principales:	Seet, Li Fong, Tan, Yang Fei, Toh, Li Zhen, Chu, Stephanie WL, Lee, Ying Shi, Venkatraman, Subbu S, Wong, Tina T
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BMJ Publishing Group 2018
Materias:	Laboratory Science
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6173823/ https://www.ncbi.nlm.nih.gov/pubmed/30021812 http://dx.doi.org/10.1136/bjophthalmol-2018-311937

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