Cargando…

Single Cell RNA Sequencing Identifies HSPG2 and APLNR as Markers of Endothelial Cell Injury in Systemic Sclerosis Skin

Objective: The mechanisms that lead to endothelial cell (EC) injury and propagate the vasculopathy in Systemic Sclerosis (SSc) are not well understood. Using single cell RNA sequencing (scRNA-seq), our goal was to identify EC markers and signature pathways associated with vascular injury in SSc skin...

Descripción completa

Detalles Bibliográficos
Autores principales:	Apostolidis, Sokratis A., Stifano, Giuseppina, Tabib, Tracy, Rice, Lisa M., Morse, Christina M., Kahaleh, Bashar, Lafyatis, Robert
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2018
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6174292/ https://www.ncbi.nlm.nih.gov/pubmed/30327649 http://dx.doi.org/10.3389/fimmu.2018.02191

Ejemplares similares

Myofibroblast transcriptome indicates SFRP2(hi) fibroblast progenitors in systemic sclerosis skin
por: Tabib, Tracy, et al.
Publicado: (2021)

APLN/APLNR Signaling Controls Key Pathological Parameters of Glioblastoma
por: Kälin, Roland E., et al.
Publicado: (2021)

APLNR marks a cardiac progenitor derived with human induced pluripotent stem cells
por: Lam, Yin-Yu, et al.
Publicado: (2023)

Disparate Interferon Signaling and Shared Aberrant Basaloid Cells in Single-Cell Profiling of Idiopathic Pulmonary Fibrosis and Systemic Sclerosis-Associated Interstitial Lung Disease
por: Valenzi, Eleanor, et al.
Publicado: (2021)

Chronic Toll-like receptor 4 stimulation in skin induces inflammation, macrophage activation, transforming growth factor beta signature gene expression, and fibrosis
por: Stifano, Giuseppina, et al.
Publicado: (2014)

Modulation of APLNR Signaling Is Required during the Development and Maintenance of the Hematopoietic System
por: Jackson, Melany, et al.
Publicado: (2021)

Editorial: Etiopathogenesis of Systemic Sclerosis: An Update
por: Stifano, Giuseppina, et al.
Publicado: (2021)

Single-cell transcriptome conservation in a comparative analysis of fresh and cryopreserved human skin tissue: pilot in localized scleroderma
por: Mirizio, Emily, et al.
Publicado: (2020)

Correction to: Single-cell transcriptome conservation in a comparative analysis of fresh and cryopreserved human skin tissue: pilot in localized scleroderma
por: Mirizio, Emily, et al.
Publicado: (2021)

Is HSPG2 a modifier gene for Marfan syndrome?
por: Gerdes Gyuricza, Isabela, et al.
Publicado: (2020)

The HSPG syndecan is a core organizer of cholinergic synapses
por: Zhou, Xin, et al.
Publicado: (2021)

The glycoprotein GP130 governs the surface presentation of the G protein–coupled receptor APLNR
por: Trillet, Kilian, et al.
Publicado: (2021)

Tofacitinib blocks IFN-regulated biomarker genes in skin fibroblasts and keratinocytes in a systemic sclerosis trial
por: Khanna, Dinesh, et al.
Publicado: (2022)

Systemic Sclerosis (SSc) After COVID-19: A Case Report
por: Chandra, Arjun, et al.
Publicado: (2022)

HSPG-Deficient Zebrafish Uncovers Dental Aspect of Multiple Osteochondromas
por: Wiweger, Malgorzata I., et al.
Publicado: (2012)

Modular Proteoglycan Perlecan/HSPG2: Mutations, Phenotypes, and Functions
por: Martinez, Jerahme R., et al.
Publicado: (2018)

Epigenetic down‐regulation of microRNA‐126 in scleroderma endothelial cells is associated with impaired responses to VEGF and defective angiogenesis
por: Wang, Yongqing, et al.
Publicado: (2021)

A Novel Pathogenic HSPG2 Mutation in Schwartz–Jampel Syndrome
por: Lin, Po-Yu, et al.
Publicado: (2021)

MicroRNA 139-5p coordinates APLNR-CXCR4 crosstalk during vascular maturation
por: Papangeli, Irinna, et al.
Publicado: (2016)

Bosentan and macitentan prevent the endothelial-to-mesenchymal transition (EndoMT) in systemic sclerosis: in vitro study
por: Corallo, Claudio, et al.
Publicado: (2016)

Knockdown of hspg2 is associated with abnormal mandibular joint formation and neural crest cell dysfunction in zebrafish
por: Castellanos, Barbara S., et al.
Publicado: (2021)

The mycosis fungoides cutaneous microenvironment shapes dysfunctional cell trafficking, antitumor immunity, matrix interactions, and angiogenesis
por: Gaydosik, Alyxzandria M., et al.
Publicado: (2023)

Evolution of the Perlecan/HSPG2 Gene and Its Activation in Regenerating Nematostella vectensis
por: Warren, Curtis R., et al.
Publicado: (2015)

Investigation of the HSPG2 Gene in Tardive Dyskinesia – New Data and Meta-Analysis
por: Zai, Clement C., et al.
Publicado: (2018)

Lack of association between the APLNR variant rs9943582 with ischemic stroke in the Chinese Han GeneID population
por: Wang, Pengyun, et al.
Publicado: (2017)

Senescent Cells Accumulate in Systemic Sclerosis Skin
por: Shi, Bo, et al.
Publicado: (2023)

Single-Cell Transcriptome Analysis Identifies Subclusters with Inflammatory Fibroblast Responses in Localized Scleroderma
por: Werner, Giffin, et al.
Publicado: (2023)

Exome Sequencing Identifies a Rare HSPG2 Variant Associated with Familial Idiopathic Scoliosis
por: Baschal, Erin E., et al.
Publicado: (2014)

HSPG2 Mutation Association with Immune Checkpoint Inhibitor Outcome in Melanoma and Non-Small Cell Lung Cancer
por: Zhang, Wenjing, et al.
Publicado: (2022)

Characterization of the Apelin/Elabela Receptors (APLNR) in Chickens, Turtles, and Zebrafish: Identification of a Novel Apelin-Specific Receptor in Teleosts
por: Zhang, Jiannan, et al.
Publicado: (2018)

Discovery of HSPG2 (Perlecan) as a Therapeutic Target in Triple Negative Breast Cancer
por: Kalscheuer, Stephen, et al.
Publicado: (2019)

HSPG2 overexpression independently predicts poor survival in patients with acute myeloid leukemia
por: Zhou, Xiaojia, et al.
Publicado: (2020)

Transcriptional profiling of lung cell populations in idiopathic pulmonary arterial hypertension
por: Saygin, Didem, et al.
Publicado: (2020)

The Aplnr GPCR regulates myocardial progenitor development via a novel cell-non-autonomous, Gα(i/o) protein-independent pathway
por: Paskaradevan, Sivani, et al.
Publicado: (2012)

The APLNR gene polymorphism rs7119375 is associated with an increased risk of development of essential hypertension in the Chinese population: A meta-analysis
por: Yoshikawa, Masahiro, et al.
Publicado: (2020)

Ectopic Expression Screen Identifies Genes Affecting Drosophila Mesoderm Development Including the HSPG Trol
por: Trisnadi, Nathanie, et al.
Publicado: (2014)

Similarities between COVID-19 and systemic sclerosis early vasculopathy: A “viral” challenge for future research in scleroderma
por: Matucci-Cerinic, Marco, et al.
Publicado: (2021)

The Adenovirus Type 3 Dodecahedron's RGD Loop Comprises an HSPG Binding Site That Influences Integrin Binding
por: Gout, E., et al.
Publicado: (2010)

Amyloid Beta Is Internalized via Macropinocytosis, an HSPG- and Lipid Raft-Dependent and Rac1-Mediated Process
por: Nazere, Keyoumu, et al.
Publicado: (2022)

A model of anti-angiogenesis: differential transcriptosome profiling of microvascular endothelial cells from diffuse systemic sclerosis patients
por: Giusti, Betti, et al.
Publicado: (2006)

Cannot write session to /tmp/vufind_sessions/sess_mh0a10nek8lln4k0b2hf93ril6