Elemene treatment for NSCLC with multiple CNS metastases: a case report and literature review

CNS metastases are common in patients with non-small-cell lung cancer (NSCLC) and is associated with poor prognosis. In NSCLC patients with EGFR mutations, and ALK fusion oncogene, chemotherapy is ineffective; however, targeted and pulse therapies may be used as alternative treatment options. Elemen...

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Autores principales: Han, Yushan, Zhang, Xia, Lu, Yishan, Dong, Yan, Fu, Hong, Zhang, Bin, Gao, Yajie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2018
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6174310/
https://www.ncbi.nlm.nih.gov/pubmed/30323615
http://dx.doi.org/10.2147/OTT.S160970
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author Han, Yushan
Zhang, Xia
Lu, Yishan
Dong, Yan
Fu, Hong
Zhang, Bin
Gao, Yajie
author_facet Han, Yushan
Zhang, Xia
Lu, Yishan
Dong, Yan
Fu, Hong
Zhang, Bin
Gao, Yajie
author_sort Han, Yushan
collection PubMed
description CNS metastases are common in patients with non-small-cell lung cancer (NSCLC) and is associated with poor prognosis. In NSCLC patients with EGFR mutations, and ALK fusion oncogene, chemotherapy is ineffective; however, targeted and pulse therapies may be used as alternative treatment options. Elemene can cross the blood–brain barrier and enter the brain tissue. In this paper, treatment consisting of elemene injections in a case of NSCLC with brain metastases, spinal metastases and a possible complication of leptomeningeal metastases is reported, and the efficacy of elemene in treating NSCLC with CNS metastases was investigated.
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spelling pubmed-61743102018-10-15 Elemene treatment for NSCLC with multiple CNS metastases: a case report and literature review Han, Yushan Zhang, Xia Lu, Yishan Dong, Yan Fu, Hong Zhang, Bin Gao, Yajie Onco Targets Ther Case Report CNS metastases are common in patients with non-small-cell lung cancer (NSCLC) and is associated with poor prognosis. In NSCLC patients with EGFR mutations, and ALK fusion oncogene, chemotherapy is ineffective; however, targeted and pulse therapies may be used as alternative treatment options. Elemene can cross the blood–brain barrier and enter the brain tissue. In this paper, treatment consisting of elemene injections in a case of NSCLC with brain metastases, spinal metastases and a possible complication of leptomeningeal metastases is reported, and the efficacy of elemene in treating NSCLC with CNS metastases was investigated. Dove Medical Press 2018-10-02 /pmc/articles/PMC6174310/ /pubmed/30323615 http://dx.doi.org/10.2147/OTT.S160970 Text en © 2018 Han et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Case Report
Han, Yushan
Zhang, Xia
Lu, Yishan
Dong, Yan
Fu, Hong
Zhang, Bin
Gao, Yajie
Elemene treatment for NSCLC with multiple CNS metastases: a case report and literature review
title Elemene treatment for NSCLC with multiple CNS metastases: a case report and literature review
title_full Elemene treatment for NSCLC with multiple CNS metastases: a case report and literature review
title_fullStr Elemene treatment for NSCLC with multiple CNS metastases: a case report and literature review
title_full_unstemmed Elemene treatment for NSCLC with multiple CNS metastases: a case report and literature review
title_short Elemene treatment for NSCLC with multiple CNS metastases: a case report and literature review
title_sort elemene treatment for nsclc with multiple cns metastases: a case report and literature review
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6174310/
https://www.ncbi.nlm.nih.gov/pubmed/30323615
http://dx.doi.org/10.2147/OTT.S160970
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