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EEG correlates associated with the severity of gambling disorder and serum BDNF levels in patients with gambling disorder

BACKGROUND AND AIMS: This study aimed to evaluate the association between the severity of pathological gambling, serum brain-derived neurotrophic factor (BDNF) level, and the characteristics of quantitative electroencephalography (EEG) in patients with gambling disorder. METHODS: A total of 55 male...

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Autores principales: Kim, Kyoung Min, Choi, Sam-Wook, Lee, Jaewon, Kim, Jun Won
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Akadémiai Kiadó 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6174577/
https://www.ncbi.nlm.nih.gov/pubmed/29865867
http://dx.doi.org/10.1556/2006.7.2018.43
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author Kim, Kyoung Min
Choi, Sam-Wook
Lee, Jaewon
Kim, Jun Won
author_facet Kim, Kyoung Min
Choi, Sam-Wook
Lee, Jaewon
Kim, Jun Won
author_sort Kim, Kyoung Min
collection PubMed
description BACKGROUND AND AIMS: This study aimed to evaluate the association between the severity of pathological gambling, serum brain-derived neurotrophic factor (BDNF) level, and the characteristics of quantitative electroencephalography (EEG) in patients with gambling disorder. METHODS: A total of 55 male patients aged 18–65 with gambling disorder participated. The severity of pathological gambling was assessed with the nine-item Problem Gambling Severity Index from the Canadian Problem Gambling Index (CPGI-PGSI). The Beck Depression Inventory and Lubben Social Network Scale were also assessed. Serum BDNF levels were assessed from blood samples. The resting-state EEG was recorded while the eyes were closed, and the absolute power of five frequency bands was analyzed: delta (1–4 Hz), theta (4–8 Hz), alpha (8–12 Hz), beta (12–30 Hz), and gamma (30–50 Hz). RESULTS: Serum BDNF level was positively correlated with theta power in the right parietal region (P4, r = .403, p = .011), beta power in the right parietal region (P4, r = .456, p = .010), and beta power in the right temporal region (T8, r = .421, p = .008). Gambling severity (CPGI-PGSI) was positively correlated with absolute beta power in the left frontal region (F7, r = .284, p = .043) and central region [(C3, r = .292, p = .038), (C4, r = .304, p = .030)]. CONCLUSIONS: These findings support the hypothesis that right-dominant lateralized correlations between BDNF and beta and theta power reflect right-dominant brain activation in addiction. The positive correlations between beta power and the severity of gambling disorder may be associated with hyperexcitability and increased cravings. These findings contribute to a better understanding of brain-based electrophysiological changes and BDNF levels in patients with pathological gambling.
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spelling pubmed-61745772018-10-09 EEG correlates associated with the severity of gambling disorder and serum BDNF levels in patients with gambling disorder Kim, Kyoung Min Choi, Sam-Wook Lee, Jaewon Kim, Jun Won J Behav Addict Full-Length Report BACKGROUND AND AIMS: This study aimed to evaluate the association between the severity of pathological gambling, serum brain-derived neurotrophic factor (BDNF) level, and the characteristics of quantitative electroencephalography (EEG) in patients with gambling disorder. METHODS: A total of 55 male patients aged 18–65 with gambling disorder participated. The severity of pathological gambling was assessed with the nine-item Problem Gambling Severity Index from the Canadian Problem Gambling Index (CPGI-PGSI). The Beck Depression Inventory and Lubben Social Network Scale were also assessed. Serum BDNF levels were assessed from blood samples. The resting-state EEG was recorded while the eyes were closed, and the absolute power of five frequency bands was analyzed: delta (1–4 Hz), theta (4–8 Hz), alpha (8–12 Hz), beta (12–30 Hz), and gamma (30–50 Hz). RESULTS: Serum BDNF level was positively correlated with theta power in the right parietal region (P4, r = .403, p = .011), beta power in the right parietal region (P4, r = .456, p = .010), and beta power in the right temporal region (T8, r = .421, p = .008). Gambling severity (CPGI-PGSI) was positively correlated with absolute beta power in the left frontal region (F7, r = .284, p = .043) and central region [(C3, r = .292, p = .038), (C4, r = .304, p = .030)]. CONCLUSIONS: These findings support the hypothesis that right-dominant lateralized correlations between BDNF and beta and theta power reflect right-dominant brain activation in addiction. The positive correlations between beta power and the severity of gambling disorder may be associated with hyperexcitability and increased cravings. These findings contribute to a better understanding of brain-based electrophysiological changes and BDNF levels in patients with pathological gambling. Akadémiai Kiadó 2018-06-05 2018-06 /pmc/articles/PMC6174577/ /pubmed/29865867 http://dx.doi.org/10.1556/2006.7.2018.43 Text en © 2018 The Author(s) http://creativecommons.org/licenses/by-nc/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium for non-commercial purposes, provided the original author and source are credited, a link to the CC License is provided, and changes – if any – are indicated.
spellingShingle Full-Length Report
Kim, Kyoung Min
Choi, Sam-Wook
Lee, Jaewon
Kim, Jun Won
EEG correlates associated with the severity of gambling disorder and serum BDNF levels in patients with gambling disorder
title EEG correlates associated with the severity of gambling disorder and serum BDNF levels in patients with gambling disorder
title_full EEG correlates associated with the severity of gambling disorder and serum BDNF levels in patients with gambling disorder
title_fullStr EEG correlates associated with the severity of gambling disorder and serum BDNF levels in patients with gambling disorder
title_full_unstemmed EEG correlates associated with the severity of gambling disorder and serum BDNF levels in patients with gambling disorder
title_short EEG correlates associated with the severity of gambling disorder and serum BDNF levels in patients with gambling disorder
title_sort eeg correlates associated with the severity of gambling disorder and serum bdnf levels in patients with gambling disorder
topic Full-Length Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6174577/
https://www.ncbi.nlm.nih.gov/pubmed/29865867
http://dx.doi.org/10.1556/2006.7.2018.43
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