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Mutations in Homocysteine Metabolism Genes Increase Keratin N-Homocysteinylation and Damage in Mice

Genetic or nutritional deficiencies in homocysteine (Hcy) metabolism increase Hcy-thiolactone, which causes protein damage by forming isopetide bonds with lysine residues, generating N-Hcy-protein. In the present work, we studied the prevalence and genetic determinants of keratin damage caused by ho...

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Detalles Bibliográficos
Autores principales:	Borowczyk, Kamila, Wróblewski, Jacek, Suliburska, Joanna, Akahoshi, Noriyuki, Ishii, Isao, Jakubowski, Hieronim
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6174792/ https://www.ncbi.nlm.nih.gov/pubmed/30345292 http://dx.doi.org/10.1155/2018/7570850

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