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M1 Macrophage Polarization Is Dependent on TRPC1-Mediated Calcium Entry

Macrophage plasticity is essential for innate immunity, but in-depth signaling mechanism(s) regulating their functional phenotypes are ill-defined. Here we report that interferon (IFN) γ priming of naive macrophages induces store-mediated Ca(2+) entry and inhibition of Ca(2+) entry impairs polarizat...

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Detalles Bibliográficos
Autores principales:	Chauhan, Arun, Sun, Yuyang, Sukumaran, Pramod, Quenum Zangbede, Fredice O., Jondle, Christopher N., Sharma, Atul, Evans, Dustin L., Chauhan, Pooja, Szlabick, Randolph E., Aaland, Mary O., Birnbaumer, Lutz, Sharma, Jyotika, Singh, Brij B., Mishra, Bibhuti B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6174824/ https://www.ncbi.nlm.nih.gov/pubmed/30293012 http://dx.doi.org/10.1016/j.isci.2018.09.014

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