Restoration of SERCA ATPase prevents oxidative stress-related muscle atrophy and weakness

Molecular targets to reduce muscle weakness and atrophy due to oxidative stress have been elusive. Here we show that activation of Sarcoplasmic Reticulum (SR) Ca(2+) ATPase (SERCA) with CDN1163, a novel small molecule allosteric SERCA activator, ameliorates the muscle impairment in the CuZnSOD defic...

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Detalles Bibliográficos
Autores principales: Qaisar, Rizwan, Bhaskaran, Shylesh, Ranjit, Rojina, Sataranatarajan, Kavithalakshmi, Premkumar, Pavithra, Huseman, Kendra, Van Remmen, Holly
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6174848/
https://www.ncbi.nlm.nih.gov/pubmed/30296699
http://dx.doi.org/10.1016/j.redox.2018.09.018

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