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Noncoding RNAs in disease
Noncoding RNAs are emerging as potent and multifunctional regulators in all biological processes. In parallel, a rapidly growing number of studies has unravelled associations between aberrant noncoding RNA expression and human diseases. These associations have been extensively reviewed, often with t...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6174949/ https://www.ncbi.nlm.nih.gov/pubmed/29972883 http://dx.doi.org/10.1002/1873-3468.13182 |
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author | Lekka, Evangelia Hall, Jonathan |
author_facet | Lekka, Evangelia Hall, Jonathan |
author_sort | Lekka, Evangelia |
collection | PubMed |
description | Noncoding RNAs are emerging as potent and multifunctional regulators in all biological processes. In parallel, a rapidly growing number of studies has unravelled associations between aberrant noncoding RNA expression and human diseases. These associations have been extensively reviewed, often with the focus on a particular microRNA (miRNA) (family) or a selected disease/pathology. In this Mini‐Review, we highlight a selection of studies in order to demonstrate the wide‐scale involvement of miRNAs and long noncoding RNAs in the pathophysiology of three types of diseases: cancer, cardiovascular and neurological disorders. This research is opening new avenues to novel therapeutic approaches. |
format | Online Article Text |
id | pubmed-6174949 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-61749492018-10-15 Noncoding RNAs in disease Lekka, Evangelia Hall, Jonathan FEBS Lett Review Articles Noncoding RNAs are emerging as potent and multifunctional regulators in all biological processes. In parallel, a rapidly growing number of studies has unravelled associations between aberrant noncoding RNA expression and human diseases. These associations have been extensively reviewed, often with the focus on a particular microRNA (miRNA) (family) or a selected disease/pathology. In this Mini‐Review, we highlight a selection of studies in order to demonstrate the wide‐scale involvement of miRNAs and long noncoding RNAs in the pathophysiology of three types of diseases: cancer, cardiovascular and neurological disorders. This research is opening new avenues to novel therapeutic approaches. John Wiley and Sons Inc. 2018-07-20 2018-09 /pmc/articles/PMC6174949/ /pubmed/29972883 http://dx.doi.org/10.1002/1873-3468.13182 Text en © The Authors. FEBS Letters published by John Wiley & Sons Ltd on behalf of Federation of European Biochemical Societies This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Articles Lekka, Evangelia Hall, Jonathan Noncoding RNAs in disease |
title | Noncoding RNAs in disease |
title_full | Noncoding RNAs in disease |
title_fullStr | Noncoding RNAs in disease |
title_full_unstemmed | Noncoding RNAs in disease |
title_short | Noncoding RNAs in disease |
title_sort | noncoding rnas in disease |
topic | Review Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6174949/ https://www.ncbi.nlm.nih.gov/pubmed/29972883 http://dx.doi.org/10.1002/1873-3468.13182 |
work_keys_str_mv | AT lekkaevangelia noncodingrnasindisease AT halljonathan noncodingrnasindisease |