Cargando…

Islet stress, degradation and autoimmunity

β‐cell destruction in type 1 diabetes (T1D) results from the effect of inflammation and autoimmunity. In response to inflammatory signals, islet cells engage adaptive mechanisms to restore and maintain cellular homeostasis. Among these mechanisms, the unfolded protein response (UPR) leads to a reduc...

Descripción completa

Detalles Bibliográficos
Autores principales:	Thomaidou, Sofia, Zaldumbide, Arnaud, Roep, Bart O.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Blackwell Publishing Ltd 2018
Materias:	Review Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6174957/ https://www.ncbi.nlm.nih.gov/pubmed/30230178 http://dx.doi.org/10.1111/dom.13387

Ejemplares similares

Type 1 diabetes mellitus as a disease of the β-cell (do not blame the immune system?)
por: Roep, Bart O., et al.
Publicado: (2020)

IFNɣ but not IFNα increases recognition of insulin defective ribosomal product-derived antigen to amplify islet autoimmunity
por: Thomaidou, Sofia, et al.
Publicado: (2023)

Bioluminescent reporter assay for monitoring ER stress in human beta cells
por: Kracht, Maria J. L., et al.
Publicado: (2018)

Cellular Islet Autoimmunity Associates with Clinical Outcome of Islet Cell Transplantation
por: Huurman, Volkert A. L., et al.
Publicado: (2008)

Islet-Resident Dendritic Cells and Macrophages in Type 1 Diabetes: In Search of Bigfoot’s Print
por: Zirpel, Henner, et al.
Publicado: (2021)

Current Advances and Travails in Islet Transplantation
por: Harlan, David M., et al.
Publicado: (2009)

Clinical and genetic correlates of islet-autoimmune signatures in juvenile-onset type 1 diabetes
por: Claessens, Laura A., et al.
Publicado: (2019)

β-Cells, Autoimmunity, and the Innate Immune System: “un Ménage á Trois”?
por: Roep, Bart O.
Publicado: (2013)

Editorial: Autoimmune Diabetes: Molecular Mechanisms and Neoantigens
por: Kent, Sally C., et al.
Publicado: (2022)

Presence of immunogenic alternatively spliced insulin gene product in human pancreatic delta cells
por: van Tienhoven, René, et al.
Publicado: (2023)

Congenital beta cell defects are not associated with markers of islet autoimmunity, even in the context of high genetic risk for type 1 diabetes
por: Wyatt, Rebecca C., et al.
Publicado: (2022)

Autoimmunity in Autologous Islet Transplantation
por: Ali, Khawla F., et al.
Publicado: (2018)

Functional Impact of Risk Gene Variants on the Autoimmune Responses in Type 1 Diabetes
por: Gootjes, Chelsea, et al.
Publicado: (2022)

Syntaxin 4 Expression in Pancreatic β-Cells Promotes Islet Function and Protects Functional β-Cell Mass
por: Oh, Eunjin, et al.
Publicado: (2018)

Adenoviral Vectors Stimulate Glucagon Transcription in Human Mesenchymal Stem Cells Expressing Pancreatic Transcription Factors
por: Zaldumbide, Arnaud, et al.
Publicado: (2012)

Serum Cytokines as Biomarkers in Islet Cell Transplantation for Type 1 Diabetes
por: van der Torren, Cornelis R., et al.
Publicado: (2016)

Proteasomal Degradation of Proinsulin Requires Derlin-2, HRD1 and p97
por: Hoelen, Hanneke, et al.
Publicado: (2015)

Graves Hyperthyroidism After Stopping Immunosuppressive Therapy in Type 1 Diabetic Islet Cell Recipients With Pretransplant TPO Autoantibodies
por: Gillard, Pieter, et al.
Publicado: (2009)

ADAR1-dependent editing regulates human β cell transcriptome diversity during inflammation
por: Szymczak, Florian, et al.
Publicado: (2022)

Chronic marijuana usage by human pancreas donors is associated with impaired islet function
por: Qi, Meirigeng, et al.
Publicado: (2021)

Naturally Arising Human CD4 T-Cells That Recognize Islet Autoantigens and Secrete Interleukin-10 Regulate Proinflammatory T-Cell Responses via Linked Suppression
por: Tree, Timothy I.M., et al.
Publicado: (2010)

The role of T cell miRNAs for regulatory T cell induction in islet autoimmunity
por: Scherm, Martin G., et al.
Publicado: (2019)

The Multifactorial Progression from the Islet Autoimmunity to Type 1 Diabetes in Children
por: Bauer, Witold, et al.
Publicado: (2021)

Human islet T cells are highly reactive to preproinsulin in type 1 diabetes
por: Anderson, Amanda M., et al.
Publicado: (2021)

Local Autoantigen Expression as Essential Gatekeeper of Memory T-Cell Recruitment to Islet Grafts in Diabetic Hosts
por: Alkemade, Gonnie M., et al.
Publicado: (2013)

Induction of tolerance to autoimmune diabetes with islet antigens
Publicado: (1992)

Innate and adaptive immunity to human beta cell lines: implications for beta cell therapy
por: van der Torren, Cornelis R., et al.
Publicado: (2015)

Relative Frequency of Islet Autoimmunity in Children and Adolescents with Autoimmune Thyroid Disease
por: Putarek, Natasa Rojnic, et al.
Publicado: (2023)

Immunogenicity of human embryonic stem cell-derived beta cells
por: van der Torren, Cornelis R., et al.
Publicado: (2016)

Regulation of T Follicular Helper Cells in Islet Autoimmunity
por: Serr, Isabelle, et al.
Publicado: (2018)

Etiology of Autoimmune Islet Disease: Timing Is Everything
por: Lernmark, Åke
Publicado: (2021)

Abnormal islet sphingolipid metabolism in type 1 diabetes
por: Holm, Laurits J., et al.
Publicado: (2018)

Heterogeneity of circulating CD8 T-cells specific to islet, neo-antigen and virus in patients with type 1 diabetes mellitus
por: Laban, Sandra, et al.
Publicado: (2018)

Demonstration of islet-autoreactive CD8 T cells in insulitic lesions from recent onset and long-term type 1 diabetes patients
por: Coppieters, Ken T., et al.
Publicado: (2012)

Metabolite-related dietary patterns and the development of islet autoimmunity
por: Johnson, Randi K., et al.
Publicado: (2019)

Influence of Vitamin D on Islet Autoimmunity and Beta-Cell Function in Type 1 Diabetes
por: Infante, Marco, et al.
Publicado: (2019)

RNA degradation in antiviral immunity and autoimmunity
por: Rigby, Rachel E., et al.
Publicado: (2015)

Autoimmune thyroid disease correlates to islet autoimmunity on zinc transporter 8 autoantibody
por: Cai, Yun, et al.
Publicado: (2021)

There Is Something About Insulin Granules
por: Roep, Bart O.
Publicado: (2020)

The need and benefit of immune monitoring to define patient and disease heterogeneity, mechanisms of therapeutic action and efficacy of intervention therapy for precision medicine in type 1 diabetes
por: Roep, Bart O.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_kigunal4f8jro21lmq2tedk971