Review: What Is the Current Evidence for Disease Subsets in Giant Cell Arteritis?

Giant cell arteritis (GCA) is an autoimmune vasculitis affecting large and medium‐sized arteries. Ample evidence indicates that GCA is a heterogeneous disease in terms of symptoms, immune pathology, and response to treatment. In the current review, we discuss the evidence for disease subsets in GCA....

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Autores principales: van der Geest, Kornelis S. M., Sandovici, Maria, van Sleen, Yannick, Sanders, Jan‐Stephan, Bos, Nicolaas A., Abdulahad, Wayel H., Stegeman, Coen A., Heeringa, Peter, Rutgers, Abraham, Kallenberg, Cees G. M., Boots, Annemieke M. H., Brouwer, Elisabeth
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Special Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6175064/
https://www.ncbi.nlm.nih.gov/pubmed/29648680
http://dx.doi.org/10.1002/art.40520
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author van der Geest, Kornelis S. M.
Sandovici, Maria
van Sleen, Yannick
Sanders, Jan‐Stephan
Bos, Nicolaas A.
Abdulahad, Wayel H.
Stegeman, Coen A.
Heeringa, Peter
Rutgers, Abraham
Kallenberg, Cees G. M.
Boots, Annemieke M. H.
Brouwer, Elisabeth
author_facet van der Geest, Kornelis S. M.
Sandovici, Maria
van Sleen, Yannick
Sanders, Jan‐Stephan
Bos, Nicolaas A.
Abdulahad, Wayel H.
Stegeman, Coen A.
Heeringa, Peter
Rutgers, Abraham
Kallenberg, Cees G. M.
Boots, Annemieke M. H.
Brouwer, Elisabeth
author_sort van der Geest, Kornelis S. M.
collection PubMed
description Giant cell arteritis (GCA) is an autoimmune vasculitis affecting large and medium‐sized arteries. Ample evidence indicates that GCA is a heterogeneous disease in terms of symptoms, immune pathology, and response to treatment. In the current review, we discuss the evidence for disease subsets in GCA. We describe clinical and immunologic characteristics that may impact the risk of cranial ischemic symptoms, relapse rates, and long‐term glucocorticoid requirements in patients with GCA. In addition, we discuss both proven and putative immunologic targets for therapy in patients with GCA who have an unfavorable prognosis. Finally, we provide recommendations for further research on disease subsets in GCA.
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spelling pubmed-61750642018-10-15 Review: What Is the Current Evidence for Disease Subsets in Giant Cell Arteritis? van der Geest, Kornelis S. M. Sandovici, Maria van Sleen, Yannick Sanders, Jan‐Stephan Bos, Nicolaas A. Abdulahad, Wayel H. Stegeman, Coen A. Heeringa, Peter Rutgers, Abraham Kallenberg, Cees G. M. Boots, Annemieke M. H. Brouwer, Elisabeth Arthritis Rheumatol Special Articles Giant cell arteritis (GCA) is an autoimmune vasculitis affecting large and medium‐sized arteries. Ample evidence indicates that GCA is a heterogeneous disease in terms of symptoms, immune pathology, and response to treatment. In the current review, we discuss the evidence for disease subsets in GCA. We describe clinical and immunologic characteristics that may impact the risk of cranial ischemic symptoms, relapse rates, and long‐term glucocorticoid requirements in patients with GCA. In addition, we discuss both proven and putative immunologic targets for therapy in patients with GCA who have an unfavorable prognosis. Finally, we provide recommendations for further research on disease subsets in GCA. John Wiley and Sons Inc. 2018-07-30 2018-09 /pmc/articles/PMC6175064/ /pubmed/29648680 http://dx.doi.org/10.1002/art.40520 Text en © 2018, The Authors Arthritis & Rheumatology published by Wiley Periodicals, Inc. on behalf of American College of Rheumatology This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Special Articles
van der Geest, Kornelis S. M.
Sandovici, Maria
van Sleen, Yannick
Sanders, Jan‐Stephan
Bos, Nicolaas A.
Abdulahad, Wayel H.
Stegeman, Coen A.
Heeringa, Peter
Rutgers, Abraham
Kallenberg, Cees G. M.
Boots, Annemieke M. H.
Brouwer, Elisabeth
Review: What Is the Current Evidence for Disease Subsets in Giant Cell Arteritis?
title Review: What Is the Current Evidence for Disease Subsets in Giant Cell Arteritis?
title_full Review: What Is the Current Evidence for Disease Subsets in Giant Cell Arteritis?
title_fullStr Review: What Is the Current Evidence for Disease Subsets in Giant Cell Arteritis?
title_full_unstemmed Review: What Is the Current Evidence for Disease Subsets in Giant Cell Arteritis?
title_short Review: What Is the Current Evidence for Disease Subsets in Giant Cell Arteritis?
title_sort review: what is the current evidence for disease subsets in giant cell arteritis?
topic Special Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6175064/
https://www.ncbi.nlm.nih.gov/pubmed/29648680
http://dx.doi.org/10.1002/art.40520
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