The role of β‐barrels 1 and 2 in the enzymatic activity of factor XIII A‐subunit

ESSENTIALS: The roles of β‐barrels 1 and 2 in factor XIII (FXIII) are currently unknown. FXIII truncations lacking β‐barrel 2, both β‐barrels, or full length FXIII, were made. Removing β‐barrel 2 caused total loss of activity, removing both β‐barrels returned 30% activity. β‐barrel 2 is necessary fo...

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Detalles Bibliográficos
Autores principales: Hethershaw, E. L., Adamson, P. J., Smith, K. A., Goldsberry, W. N., Pease, R. J., Radford, S. E., Grant, P. J., Ariëns, R. A. S., Maurer, M. C., Philippou, H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
COAGULATION
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6175083/
https://www.ncbi.nlm.nih.gov/pubmed/29675848
http://dx.doi.org/10.1111/jth.14128

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