Cargando…
Common and well‐documented HLA alleles of German stem cell donors by haplotype frequency estimation
We present a catalog of common and well‐documented (CWD) alleles of the German population for the six HLA loci A, B, C, DRB1, DQB1, and DPB1. This study is based on a sample of over 5 million volunteer adult hematopoietic stem cell donors from the 26 German donor centers. To establish the catalog, a...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Blackwell Publishing Ltd
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6175154/ https://www.ncbi.nlm.nih.gov/pubmed/30117303 http://dx.doi.org/10.1111/tan.13378 |
_version_ | 1783361438308368384 |
---|---|
author | Eberhard, Hans‐Peter Schmidt, Alexander H. Mytilineos, Joannis Fleischhauer, Katharina Müller, Carlheinz R. |
author_facet | Eberhard, Hans‐Peter Schmidt, Alexander H. Mytilineos, Joannis Fleischhauer, Katharina Müller, Carlheinz R. |
author_sort | Eberhard, Hans‐Peter |
collection | PubMed |
description | We present a catalog of common and well‐documented (CWD) alleles of the German population for the six HLA loci A, B, C, DRB1, DQB1, and DPB1. This study is based on a sample of over 5 million volunteer adult hematopoietic stem cell donors from the 26 German donor centers. To establish the catalog, allele and haplotype frequencies were estimated with a validated implementation of the expectation‐maximization algorithm. CWD criteria similar to existing CWD catalogs were applied in order to be able to put our findings into the context of relevant existing references. Overall, 2155 HLA‐A, ‐B, ‐C, ‐DRB1, ‐DQB1, and ‐DPB1 alleles were identified as CWD in the German donor population representing about 20% of the HLA alleles at two‐field resolution in the IPD‐IMGT/HLA Database release v3.25.0 from July 2016 for these six loci. We found a substantial concordance of CWD alleles between the three catalogs and showed the contribution of the German donor population to the CWD alleles domain. In conclusion, the definition of CWD criteria that allow interoperability, scalability, and flexibility will be crucial for the development of a worldwide CWD catalog. |
format | Online Article Text |
id | pubmed-6175154 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Blackwell Publishing Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-61751542018-10-15 Common and well‐documented HLA alleles of German stem cell donors by haplotype frequency estimation Eberhard, Hans‐Peter Schmidt, Alexander H. Mytilineos, Joannis Fleischhauer, Katharina Müller, Carlheinz R. HLA Original Articles We present a catalog of common and well‐documented (CWD) alleles of the German population for the six HLA loci A, B, C, DRB1, DQB1, and DPB1. This study is based on a sample of over 5 million volunteer adult hematopoietic stem cell donors from the 26 German donor centers. To establish the catalog, allele and haplotype frequencies were estimated with a validated implementation of the expectation‐maximization algorithm. CWD criteria similar to existing CWD catalogs were applied in order to be able to put our findings into the context of relevant existing references. Overall, 2155 HLA‐A, ‐B, ‐C, ‐DRB1, ‐DQB1, and ‐DPB1 alleles were identified as CWD in the German donor population representing about 20% of the HLA alleles at two‐field resolution in the IPD‐IMGT/HLA Database release v3.25.0 from July 2016 for these six loci. We found a substantial concordance of CWD alleles between the three catalogs and showed the contribution of the German donor population to the CWD alleles domain. In conclusion, the definition of CWD criteria that allow interoperability, scalability, and flexibility will be crucial for the development of a worldwide CWD catalog. Blackwell Publishing Ltd 2018-09-25 2018-10 /pmc/articles/PMC6175154/ /pubmed/30117303 http://dx.doi.org/10.1111/tan.13378 Text en © 2018 The Authors. HLA published by John Wiley & Sons Ltd. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
spellingShingle | Original Articles Eberhard, Hans‐Peter Schmidt, Alexander H. Mytilineos, Joannis Fleischhauer, Katharina Müller, Carlheinz R. Common and well‐documented HLA alleles of German stem cell donors by haplotype frequency estimation |
title | Common and well‐documented HLA alleles of German stem cell donors by haplotype frequency estimation |
title_full | Common and well‐documented HLA alleles of German stem cell donors by haplotype frequency estimation |
title_fullStr | Common and well‐documented HLA alleles of German stem cell donors by haplotype frequency estimation |
title_full_unstemmed | Common and well‐documented HLA alleles of German stem cell donors by haplotype frequency estimation |
title_short | Common and well‐documented HLA alleles of German stem cell donors by haplotype frequency estimation |
title_sort | common and well‐documented hla alleles of german stem cell donors by haplotype frequency estimation |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6175154/ https://www.ncbi.nlm.nih.gov/pubmed/30117303 http://dx.doi.org/10.1111/tan.13378 |
work_keys_str_mv | AT eberhardhanspeter commonandwelldocumentedhlaallelesofgermanstemcelldonorsbyhaplotypefrequencyestimation AT schmidtalexanderh commonandwelldocumentedhlaallelesofgermanstemcelldonorsbyhaplotypefrequencyestimation AT mytilineosjoannis commonandwelldocumentedhlaallelesofgermanstemcelldonorsbyhaplotypefrequencyestimation AT fleischhauerkatharina commonandwelldocumentedhlaallelesofgermanstemcelldonorsbyhaplotypefrequencyestimation AT mullercarlheinzr commonandwelldocumentedhlaallelesofgermanstemcelldonorsbyhaplotypefrequencyestimation |