Evidence for the Role of Intracellular Water Lifetime as a Tumour Biomarker Obtained by In Vivo Field‐Cycling Relaxometry

It was established through in vivo T(1) measurements at low magnetic fields that tumour cells display proton T(1) values that are markedly longer than those shown by healthy tissue. Moreover, it has been found that the elongation of T(1) parallels the aggressiveness of the investigated tumour. The T...

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Autores principales: Ruggiero, Maria Rosaria, Baroni, Simona, Pezzana, Stefania, Ferrante, Gianni, Geninatti Crich, Simonetta, Aime, Silvio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6175164/
https://www.ncbi.nlm.nih.gov/pubmed/29575414
http://dx.doi.org/10.1002/anie.201713318
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author Ruggiero, Maria Rosaria
Baroni, Simona
Pezzana, Stefania
Ferrante, Gianni
Geninatti Crich, Simonetta
Aime, Silvio
author_facet Ruggiero, Maria Rosaria
Baroni, Simona
Pezzana, Stefania
Ferrante, Gianni
Geninatti Crich, Simonetta
Aime, Silvio
author_sort Ruggiero, Maria Rosaria
collection PubMed
description It was established through in vivo T(1) measurements at low magnetic fields that tumour cells display proton T(1) values that are markedly longer than those shown by healthy tissue. Moreover, it has been found that the elongation of T(1) parallels the aggressiveness of the investigated tumour. The T(1) lengthening is associated with an enhanced water exchange rate across the transcytolemmal membrane through an overexpression/upregulation of GLUT1 and Na(+)/K(+) ATPase transporters. It follows that the intracellular water lifetime represents a hallmark of tumour cells that can be easily monitored by measuring T(1) at different magnetic field strengths ranging from 0.2 to 200 mT.
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spelling pubmed-61751642018-10-15 Evidence for the Role of Intracellular Water Lifetime as a Tumour Biomarker Obtained by In Vivo Field‐Cycling Relaxometry Ruggiero, Maria Rosaria Baroni, Simona Pezzana, Stefania Ferrante, Gianni Geninatti Crich, Simonetta Aime, Silvio Angew Chem Int Ed Engl Communications It was established through in vivo T(1) measurements at low magnetic fields that tumour cells display proton T(1) values that are markedly longer than those shown by healthy tissue. Moreover, it has been found that the elongation of T(1) parallels the aggressiveness of the investigated tumour. The T(1) lengthening is associated with an enhanced water exchange rate across the transcytolemmal membrane through an overexpression/upregulation of GLUT1 and Na(+)/K(+) ATPase transporters. It follows that the intracellular water lifetime represents a hallmark of tumour cells that can be easily monitored by measuring T(1) at different magnetic field strengths ranging from 0.2 to 200 mT. John Wiley and Sons Inc. 2018-04-14 2018-06-18 /pmc/articles/PMC6175164/ /pubmed/29575414 http://dx.doi.org/10.1002/anie.201713318 Text en © 2018 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Communications
Ruggiero, Maria Rosaria
Baroni, Simona
Pezzana, Stefania
Ferrante, Gianni
Geninatti Crich, Simonetta
Aime, Silvio
Evidence for the Role of Intracellular Water Lifetime as a Tumour Biomarker Obtained by In Vivo Field‐Cycling Relaxometry
title Evidence for the Role of Intracellular Water Lifetime as a Tumour Biomarker Obtained by In Vivo Field‐Cycling Relaxometry
title_full Evidence for the Role of Intracellular Water Lifetime as a Tumour Biomarker Obtained by In Vivo Field‐Cycling Relaxometry
title_fullStr Evidence for the Role of Intracellular Water Lifetime as a Tumour Biomarker Obtained by In Vivo Field‐Cycling Relaxometry
title_full_unstemmed Evidence for the Role of Intracellular Water Lifetime as a Tumour Biomarker Obtained by In Vivo Field‐Cycling Relaxometry
title_short Evidence for the Role of Intracellular Water Lifetime as a Tumour Biomarker Obtained by In Vivo Field‐Cycling Relaxometry
title_sort evidence for the role of intracellular water lifetime as a tumour biomarker obtained by in vivo field‐cycling relaxometry
topic Communications
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6175164/
https://www.ncbi.nlm.nih.gov/pubmed/29575414
http://dx.doi.org/10.1002/anie.201713318
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