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Functional Characterization of the Osteoarthritis Genetic Risk Residing at ALDH1A2 Identifies rs12915901 as a Key Target Variant
OBJECTIVE: To identify the functional single‐nucleotide polymorphisms (SNPs) and mechanisms conferring increased risk of hand osteoarthritis (OA) at the ALDH1A2 locus, which is a retinoic acid regulatory gene. METHODS: Tissue samples from 247 patients with knee, hip, or hand OA who had undergone joi...
Autores principales: | Shepherd, Colin, Zhu, Dongxing, Skelton, Andrew J., Combe, Jennifer, Threadgold, Harrison, Zhu, Linyi, Vincent, Tonia L., Stuart, Paul, Reynard, Louise N., Loughlin, John |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6175168/ https://www.ncbi.nlm.nih.gov/pubmed/29732726 http://dx.doi.org/10.1002/art.40545 |
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