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Polymorphic Phase Transitions in Carbamazepine and 10,11‐Dihydrocarbamazepine
Temperature‐induced phase transitions in carbamazepine (CBZ) and 10,11‐dihydrocarbamazepine (DHC) were studied by simultaneous differential scanning calorimetry–X‐ray diffraction in this work. The transitions generally involve a transitional melt phase which is quickly followed by recrystallisation....
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6175174/ https://www.ncbi.nlm.nih.gov/pubmed/29979477 http://dx.doi.org/10.1002/chem.201802368 |
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author | Clout, Alexander E. Buanz, Asma B. M. Gaisford, Simon Williams, Gareth R. |
author_facet | Clout, Alexander E. Buanz, Asma B. M. Gaisford, Simon Williams, Gareth R. |
author_sort | Clout, Alexander E. |
collection | PubMed |
description | Temperature‐induced phase transitions in carbamazepine (CBZ) and 10,11‐dihydrocarbamazepine (DHC) were studied by simultaneous differential scanning calorimetry–X‐ray diffraction in this work. The transitions generally involve a transitional melt phase which is quickly followed by recrystallisation. The expansions of the unit cell as a function of temperature could be quantified and allow us to determine a directional order of stability in relation to the lattice constants. Dihydrocarbamazepine form II undergoes a conversion to form I by a localised melt phase. Carbamazepine (CBZ) form IV converts to form I at 182 °C, again by a localised intermediate melt phase. CBZ form II converted to form I at 119 °C by a pathway that appears to have included some melting, and form III underwent a part melt‐recrystallisation and a part sublimation‐recrystallisation to form I. |
format | Online Article Text |
id | pubmed-6175174 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-61751742018-10-15 Polymorphic Phase Transitions in Carbamazepine and 10,11‐Dihydrocarbamazepine Clout, Alexander E. Buanz, Asma B. M. Gaisford, Simon Williams, Gareth R. Chemistry Full Papers Temperature‐induced phase transitions in carbamazepine (CBZ) and 10,11‐dihydrocarbamazepine (DHC) were studied by simultaneous differential scanning calorimetry–X‐ray diffraction in this work. The transitions generally involve a transitional melt phase which is quickly followed by recrystallisation. The expansions of the unit cell as a function of temperature could be quantified and allow us to determine a directional order of stability in relation to the lattice constants. Dihydrocarbamazepine form II undergoes a conversion to form I by a localised melt phase. Carbamazepine (CBZ) form IV converts to form I at 182 °C, again by a localised intermediate melt phase. CBZ form II converted to form I at 119 °C by a pathway that appears to have included some melting, and form III underwent a part melt‐recrystallisation and a part sublimation‐recrystallisation to form I. John Wiley and Sons Inc. 2018-08-20 2018-09-12 /pmc/articles/PMC6175174/ /pubmed/29979477 http://dx.doi.org/10.1002/chem.201802368 Text en © 2018 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Full Papers Clout, Alexander E. Buanz, Asma B. M. Gaisford, Simon Williams, Gareth R. Polymorphic Phase Transitions in Carbamazepine and 10,11‐Dihydrocarbamazepine |
title | Polymorphic Phase Transitions in Carbamazepine and 10,11‐Dihydrocarbamazepine |
title_full | Polymorphic Phase Transitions in Carbamazepine and 10,11‐Dihydrocarbamazepine |
title_fullStr | Polymorphic Phase Transitions in Carbamazepine and 10,11‐Dihydrocarbamazepine |
title_full_unstemmed | Polymorphic Phase Transitions in Carbamazepine and 10,11‐Dihydrocarbamazepine |
title_short | Polymorphic Phase Transitions in Carbamazepine and 10,11‐Dihydrocarbamazepine |
title_sort | polymorphic phase transitions in carbamazepine and 10,11‐dihydrocarbamazepine |
topic | Full Papers |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6175174/ https://www.ncbi.nlm.nih.gov/pubmed/29979477 http://dx.doi.org/10.1002/chem.201802368 |
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