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Toll‐Like Receptor 9 Deficiency Breaks Tolerance to RNA‐Associated Antigens and Up‐Regulates Toll‐Like Receptor 7 Protein in Sle1 Mice

OBJECTIVE: Toll‐like receptors (TLRs) 7 and 9 are important innate signaling molecules with opposing roles in the development and progression of systemic lupus erythematosus (SLE). While multiple studies support the notion of a dependency on TLR‐7 for disease development, genetic ablation of TLR‐9 r...

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Detalles Bibliográficos
Autores principales:	Celhar, Teja, Yasuga, Hiroko, Lee, Hui Yin, Zharkova, Olga, Tripathi, Shubhita, Thornhill, Susannah I., Lu, Hao K., Au, Bijin, Lim, Lina H. K., Thamboo, Thomas P., Akira, Shizuo, Wakeland, Edward K., Connolly, John E., Fairhurst, Anna‐Marie
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2018
Materias:	Systemic Lupus Erythematosus
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6175219/ https://www.ncbi.nlm.nih.gov/pubmed/29687651 http://dx.doi.org/10.1002/art.40535

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