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In Vivo Assessment of the Effect of CYP1A2 Inhibition and Induction on Pomalidomide Pharmacokinetics in Healthy Subjects

Pomalidomide is an immunomodulatory drug, and the dosage of 4 mg per day taken orally on days 1‐21 of repeated 28‐day cycles has been approved in the European Union and the United States to treat patients with relapsed/refractory multiple myeloma. In vitro data showed that pomalidomide is a substrat...

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Detalles Bibliográficos
Autores principales:	Li, Yan, Liu, Liangang, Wang, Xiaomin, Zhang, Chengyue, Reyes, Josephine, Hoffmann, Matthew, Palmisano, Maria, Zhou, Simon
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2018
Materias:	Drug Interactions
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6175223/ https://www.ncbi.nlm.nih.gov/pubmed/29762875 http://dx.doi.org/10.1002/jcph.1145

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