EWS‐FLI1 reprograms the metabolism of Ewing sarcoma cells via positive regulation of glutamine import and serine‐glycine biosynthesis

Ewing sarcoma (EWS) is a soft tissue and bone tumor that occurs primarily in adolescents and young adults. In most cases of EWS, the chimeric transcription factor, EWS‐FLI1 is the primary oncogenic driver. The epigenome of EWS cells reflects EWS‐FLI1 binding and activation or repression of transcrip...

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Detalles Bibliográficos
Autores principales: Sen, Nirmalya, Cross, Allison M., Lorenzi, Philip L., Khan, Javed, Gryder, Berkley E., Kim, Suntae, Caplen, Natasha J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6175245/
https://www.ncbi.nlm.nih.gov/pubmed/29873416
http://dx.doi.org/10.1002/mc.22849

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6175245/
https://www.ncbi.nlm.nih.gov/pubmed/29873416
http://dx.doi.org/10.1002/mc.22849

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