Na(+)‐taurocholate cotransporting polypeptide inhibition has hepatoprotective effects in cholestasis in mice

Accumulation of bile salts (BSs) during cholestasis leads to hepatic and biliary injury, driving inflammatory and fibrotic processes. The Na(+)‐Taurocholate Cotransporting Polypeptide (NTCP) is the major hepatic uptake transporter of BSs, and can be specifically inhibited by myrcludex B. We hypothes...

Descripción completa

Detalles Bibliográficos
Autores principales: Slijepcevic, Davor, Roscam Abbing, Reinout L.P., Fuchs, Claudia D., Haazen, Lizette C.M., Beuers, Ulrich, Trauner, Michael, Oude Elferink, Ronald P.J., van de Graaf, Stan F.J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6175374/
https://www.ncbi.nlm.nih.gov/pubmed/29572910
http://dx.doi.org/10.1002/hep.29888

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6175374/
https://www.ncbi.nlm.nih.gov/pubmed/29572910
http://dx.doi.org/10.1002/hep.29888

Ejemplares similares