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Effects of lipid‐based nutrient supplements or multiple micronutrient supplements compared with iron and folic acid supplements during pregnancy on maternal haemoglobin and iron status

We examined the effect of three types of prenatal supplements containing different amounts of iron on haemoglobin (Hb) and iron status (zinc protoporphyrin [ZPP] and soluble transferrin receptor [sTfR]) in late pregnancy among 1,379 women in rural Malawi. Participants were recruited at ≤20 gestation...

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Autores principales: Jorgensen, Josh M., Ashorn, Per, Ashorn, Ulla, Baldiviez, Lacey M., Gondwe, Austrida, Maleta, Ken, Nkhoma, Minyanga, Dewey, Kathryn G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6175407/
https://www.ncbi.nlm.nih.gov/pubmed/30047245
http://dx.doi.org/10.1111/mcn.12640
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author Jorgensen, Josh M.
Ashorn, Per
Ashorn, Ulla
Baldiviez, Lacey M.
Gondwe, Austrida
Maleta, Ken
Nkhoma, Minyanga
Dewey, Kathryn G.
author_facet Jorgensen, Josh M.
Ashorn, Per
Ashorn, Ulla
Baldiviez, Lacey M.
Gondwe, Austrida
Maleta, Ken
Nkhoma, Minyanga
Dewey, Kathryn G.
author_sort Jorgensen, Josh M.
collection PubMed
description We examined the effect of three types of prenatal supplements containing different amounts of iron on haemoglobin (Hb) and iron status (zinc protoporphyrin [ZPP] and soluble transferrin receptor [sTfR]) in late pregnancy among 1,379 women in rural Malawi. Participants were recruited at ≤20 gestational weeks (gw) and randomly assigned to consume daily (1) 60‐mg iron and folic acid (IFA); (2) 20‐mg iron plus 17 micronutrients in a capsule (MMN); or (3) lipid‐based nutrient supplement (LNS; 118 kcal) with 20‐mg iron plus 21 micronutrients, protein, and fat. We analysed differences between intervention groups in mean Hb, ZPP, and sTfR at 36 gw, and the proportion with anaemia (Hb < 100 g L(−1)) and iron deficiency (ZPP > 60 μmol mol(−1) haem or sTfR > 6 mg L(−1)) at 36 gw. Women in the IFA group had higher Hb at 36 gw than women in the LNS group (P = 0.030) and higher iron status (lower ZPP and sTfR) than women in both the LNS (P < 0.001 for both ZPP and sTfR) and MMN (P = 0.025 and P = 0.046) groups. Results for anaemia and iron deficiency showed similar trends. Further research is needed to elucidate the appropriate amount of iron to improve Hb and iron status, while improving birth outcomes.
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spelling pubmed-61754072018-10-19 Effects of lipid‐based nutrient supplements or multiple micronutrient supplements compared with iron and folic acid supplements during pregnancy on maternal haemoglobin and iron status Jorgensen, Josh M. Ashorn, Per Ashorn, Ulla Baldiviez, Lacey M. Gondwe, Austrida Maleta, Ken Nkhoma, Minyanga Dewey, Kathryn G. Matern Child Nutr Original Articles We examined the effect of three types of prenatal supplements containing different amounts of iron on haemoglobin (Hb) and iron status (zinc protoporphyrin [ZPP] and soluble transferrin receptor [sTfR]) in late pregnancy among 1,379 women in rural Malawi. Participants were recruited at ≤20 gestational weeks (gw) and randomly assigned to consume daily (1) 60‐mg iron and folic acid (IFA); (2) 20‐mg iron plus 17 micronutrients in a capsule (MMN); or (3) lipid‐based nutrient supplement (LNS; 118 kcal) with 20‐mg iron plus 21 micronutrients, protein, and fat. We analysed differences between intervention groups in mean Hb, ZPP, and sTfR at 36 gw, and the proportion with anaemia (Hb < 100 g L(−1)) and iron deficiency (ZPP > 60 μmol mol(−1) haem or sTfR > 6 mg L(−1)) at 36 gw. Women in the IFA group had higher Hb at 36 gw than women in the LNS group (P = 0.030) and higher iron status (lower ZPP and sTfR) than women in both the LNS (P < 0.001 for both ZPP and sTfR) and MMN (P = 0.025 and P = 0.046) groups. Results for anaemia and iron deficiency showed similar trends. Further research is needed to elucidate the appropriate amount of iron to improve Hb and iron status, while improving birth outcomes. John Wiley and Sons Inc. 2018-07-26 /pmc/articles/PMC6175407/ /pubmed/30047245 http://dx.doi.org/10.1111/mcn.12640 Text en © 2018 The Authors. Maternal and Child Nutrition Published by John Wiley & Sons, Ltd. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Articles
Jorgensen, Josh M.
Ashorn, Per
Ashorn, Ulla
Baldiviez, Lacey M.
Gondwe, Austrida
Maleta, Ken
Nkhoma, Minyanga
Dewey, Kathryn G.
Effects of lipid‐based nutrient supplements or multiple micronutrient supplements compared with iron and folic acid supplements during pregnancy on maternal haemoglobin and iron status
title Effects of lipid‐based nutrient supplements or multiple micronutrient supplements compared with iron and folic acid supplements during pregnancy on maternal haemoglobin and iron status
title_full Effects of lipid‐based nutrient supplements or multiple micronutrient supplements compared with iron and folic acid supplements during pregnancy on maternal haemoglobin and iron status
title_fullStr Effects of lipid‐based nutrient supplements or multiple micronutrient supplements compared with iron and folic acid supplements during pregnancy on maternal haemoglobin and iron status
title_full_unstemmed Effects of lipid‐based nutrient supplements or multiple micronutrient supplements compared with iron and folic acid supplements during pregnancy on maternal haemoglobin and iron status
title_short Effects of lipid‐based nutrient supplements or multiple micronutrient supplements compared with iron and folic acid supplements during pregnancy on maternal haemoglobin and iron status
title_sort effects of lipid‐based nutrient supplements or multiple micronutrient supplements compared with iron and folic acid supplements during pregnancy on maternal haemoglobin and iron status
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6175407/
https://www.ncbi.nlm.nih.gov/pubmed/30047245
http://dx.doi.org/10.1111/mcn.12640
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