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Intracellular sorting and transcytosis of the rat transferrin receptor antibody OX26 across the blood–brain barrier in vitro is dependent on its binding affinity

The blood–brain barrier (BBB) is a formidable obstacle to the delivery of therapeutics to the brain. Antibodies that bind transferrin receptor (TfR), which is enriched in brain endothelial cells, have been shown to cross the BBB and are being developed as fusion proteins to deliver therapeutic cargo...

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Detalles Bibliográficos
Autores principales:	Haqqani, Arsalan S., Thom, George, Burrell, Matthew, Delaney, Christie E., Brunette, Eric, Baumann, Ewa, Sodja, Caroline, Jezierski, Anna, Webster, Carl, Stanimirovic, Danica B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2018
Materias:	ORIGINAL ARTICLES
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6175443/ https://www.ncbi.nlm.nih.gov/pubmed/29877588 http://dx.doi.org/10.1111/jnc.14482

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