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MTHFR C677T and A1298C polymorphisms and lung cancer risk in a female Chinese population
OBJECTIVE: To examine the relationship between polymorphisms in the methylenetetrahydrofolate reductase (MTHFR) gene and susceptibility to lung cancer in a female Chinese population. METHOD: A hospital-based case-control study of 388 cases and 388 controls was conducted. Two polymorphisms in MTHFR w...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove Medical Press
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6175546/ https://www.ncbi.nlm.nih.gov/pubmed/30323671 http://dx.doi.org/10.2147/CMAR.S176263 |
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author | Tong, Weiwei Tong, Guanghui Jin, Dongyan Lv, Qingjie |
author_facet | Tong, Weiwei Tong, Guanghui Jin, Dongyan Lv, Qingjie |
author_sort | Tong, Weiwei |
collection | PubMed |
description | OBJECTIVE: To examine the relationship between polymorphisms in the methylenetetrahydrofolate reductase (MTHFR) gene and susceptibility to lung cancer in a female Chinese population. METHOD: A hospital-based case-control study of 388 cases and 388 controls was conducted. Two polymorphisms in MTHFR were detected using TaqMan methods. RESULTS: The MTHFR C677T polymorphism was associated with the risk of lung cancer and lung adenocarcinoma. Carriers with the TT genotype of C677T were observed to have an increased risk of lung cancer and lung adenocarcinoma (the ORs were 1.550 and 1.588, respectively). By contrast, the A1298C polymorphism had a negative relationship with the risk of lung cancer and lung adenocarcinoma; compared with the AA genotype carriers, the CC genotype carriers had a lower risk of lung cancer and adenocarcinoma in the female Chinese population (ORs were 0.302 and 0.215, respectively). In the stratified analyses, we observed only the A1298C polymorphism in the CC genotype carriers with a statistically significant reduction in the risk of non-small-cell lung cancer, compared to the AA genotype carriers. No significant statistical association was found between the MTHFR gene polymorphisms and risk of the residual subtype of lung cancer. CONCLUSION: This study provides evidence that the MTHFR C677T polymorphism may contribute to the development of lung cancer and lung adenocarcinoma in a female Chinese population. However, the MTHFR A1298C polymorphism may be associated with the decreasing risk of lung cancer. |
format | Online Article Text |
id | pubmed-6175546 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-61755462018-10-15 MTHFR C677T and A1298C polymorphisms and lung cancer risk in a female Chinese population Tong, Weiwei Tong, Guanghui Jin, Dongyan Lv, Qingjie Cancer Manag Res Original Research OBJECTIVE: To examine the relationship between polymorphisms in the methylenetetrahydrofolate reductase (MTHFR) gene and susceptibility to lung cancer in a female Chinese population. METHOD: A hospital-based case-control study of 388 cases and 388 controls was conducted. Two polymorphisms in MTHFR were detected using TaqMan methods. RESULTS: The MTHFR C677T polymorphism was associated with the risk of lung cancer and lung adenocarcinoma. Carriers with the TT genotype of C677T were observed to have an increased risk of lung cancer and lung adenocarcinoma (the ORs were 1.550 and 1.588, respectively). By contrast, the A1298C polymorphism had a negative relationship with the risk of lung cancer and lung adenocarcinoma; compared with the AA genotype carriers, the CC genotype carriers had a lower risk of lung cancer and adenocarcinoma in the female Chinese population (ORs were 0.302 and 0.215, respectively). In the stratified analyses, we observed only the A1298C polymorphism in the CC genotype carriers with a statistically significant reduction in the risk of non-small-cell lung cancer, compared to the AA genotype carriers. No significant statistical association was found between the MTHFR gene polymorphisms and risk of the residual subtype of lung cancer. CONCLUSION: This study provides evidence that the MTHFR C677T polymorphism may contribute to the development of lung cancer and lung adenocarcinoma in a female Chinese population. However, the MTHFR A1298C polymorphism may be associated with the decreasing risk of lung cancer. Dove Medical Press 2018-10-03 /pmc/articles/PMC6175546/ /pubmed/30323671 http://dx.doi.org/10.2147/CMAR.S176263 Text en © 2018 Tong et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. |
spellingShingle | Original Research Tong, Weiwei Tong, Guanghui Jin, Dongyan Lv, Qingjie MTHFR C677T and A1298C polymorphisms and lung cancer risk in a female Chinese population |
title | MTHFR C677T and A1298C polymorphisms and lung cancer risk in a female Chinese population |
title_full | MTHFR C677T and A1298C polymorphisms and lung cancer risk in a female Chinese population |
title_fullStr | MTHFR C677T and A1298C polymorphisms and lung cancer risk in a female Chinese population |
title_full_unstemmed | MTHFR C677T and A1298C polymorphisms and lung cancer risk in a female Chinese population |
title_short | MTHFR C677T and A1298C polymorphisms and lung cancer risk in a female Chinese population |
title_sort | mthfr c677t and a1298c polymorphisms and lung cancer risk in a female chinese population |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6175546/ https://www.ncbi.nlm.nih.gov/pubmed/30323671 http://dx.doi.org/10.2147/CMAR.S176263 |
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