BRCT domains of the DNA damage checkpoint proteins TOPBP1/Rad4 display distinct specificities for phosphopeptide ligands

TOPBP1 and its fission yeast homologue Rad4, are critical players in a range of DNA replication, repair and damage signalling processes. They are composed of multiple BRCT domains, some of which bind phosphorylated motifs in other proteins. They thus act as multi-point adaptors bringing proteins tog...

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Detalles Bibliográficos
Autores principales: Day, Matthew, Rappas, Mathieu, Ptasinska, Katie, Boos, Dominik, Oliver, Antony W, Pearl, Laurence H
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2018
Materias:
Biochemistry and Chemical Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6175577/
https://www.ncbi.nlm.nih.gov/pubmed/30295604
http://dx.doi.org/10.7554/eLife.39979

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6175577/
https://www.ncbi.nlm.nih.gov/pubmed/30295604
http://dx.doi.org/10.7554/eLife.39979

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