Prostaglandin A(1) inhibits the replication of bovine viral diarrhea virus

Bovine viral diarrhea virus can cause acute disease in livestock, leading to economic losses. We show that Prostaglandin A(1) inhibits bovine viral diarrhea virus replication in Madin-Darby bovine kidney cells (94% inhibition using 5 μg/mL). Light and electron microscopy of infected cells shows that...

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Detalles Bibliográficos
Autores principales: Caldas, Lúcio Ayres, Freitas, Tânia Rosária Pereira, Azevedo, Renata Campos, de Souza, Wanderley
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6175701/
https://www.ncbi.nlm.nih.gov/pubmed/29544983
http://dx.doi.org/10.1016/j.bjm.2017.12.010
Descripción
Sumario:Bovine viral diarrhea virus can cause acute disease in livestock, leading to economic losses. We show that Prostaglandin A(1) inhibits bovine viral diarrhea virus replication in Madin-Darby bovine kidney cells (94% inhibition using 5 μg/mL). Light and electron microscopy of infected cells shows that Prostaglandin A(1) also prevents virus-induced vacuolization, but at higher concentrations (10 μg/mL).

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