Prostaglandin A(1) inhibits the replication of bovine viral diarrhea virus

Bovine viral diarrhea virus can cause acute disease in livestock, leading to economic losses. We show that Prostaglandin A(1) inhibits bovine viral diarrhea virus replication in Madin-Darby bovine kidney cells (94% inhibition using 5 μg/mL). Light and electron microscopy of infected cells shows that...

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Detalles Bibliográficos
Autores principales: Caldas, Lúcio Ayres, Freitas, Tânia Rosária Pereira, Azevedo, Renata Campos, de Souza, Wanderley
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6175701/
https://www.ncbi.nlm.nih.gov/pubmed/29544983
http://dx.doi.org/10.1016/j.bjm.2017.12.010
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author Caldas, Lúcio Ayres
Freitas, Tânia Rosária Pereira
Azevedo, Renata Campos
de Souza, Wanderley
author_facet Caldas, Lúcio Ayres
Freitas, Tânia Rosária Pereira
Azevedo, Renata Campos
de Souza, Wanderley
author_sort Caldas, Lúcio Ayres
collection PubMed
description Bovine viral diarrhea virus can cause acute disease in livestock, leading to economic losses. We show that Prostaglandin A(1) inhibits bovine viral diarrhea virus replication in Madin-Darby bovine kidney cells (94% inhibition using 5 μg/mL). Light and electron microscopy of infected cells shows that Prostaglandin A(1) also prevents virus-induced vacuolization, but at higher concentrations (10 μg/mL).
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spelling pubmed-61757012018-10-09 Prostaglandin A(1) inhibits the replication of bovine viral diarrhea virus Caldas, Lúcio Ayres Freitas, Tânia Rosária Pereira Azevedo, Renata Campos de Souza, Wanderley Braz J Microbiol Research Paper Bovine viral diarrhea virus can cause acute disease in livestock, leading to economic losses. We show that Prostaglandin A(1) inhibits bovine viral diarrhea virus replication in Madin-Darby bovine kidney cells (94% inhibition using 5 μg/mL). Light and electron microscopy of infected cells shows that Prostaglandin A(1) also prevents virus-induced vacuolization, but at higher concentrations (10 μg/mL). Elsevier 2018-03-01 /pmc/articles/PMC6175701/ /pubmed/29544983 http://dx.doi.org/10.1016/j.bjm.2017.12.010 Text en © 2018 Sociedade Brasileira de Microbiologia. Published by Elsevier Editora Ltda. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Research Paper
Caldas, Lúcio Ayres
Freitas, Tânia Rosária Pereira
Azevedo, Renata Campos
de Souza, Wanderley
Prostaglandin A(1) inhibits the replication of bovine viral diarrhea virus
title Prostaglandin A(1) inhibits the replication of bovine viral diarrhea virus
title_full Prostaglandin A(1) inhibits the replication of bovine viral diarrhea virus
title_fullStr Prostaglandin A(1) inhibits the replication of bovine viral diarrhea virus
title_full_unstemmed Prostaglandin A(1) inhibits the replication of bovine viral diarrhea virus
title_short Prostaglandin A(1) inhibits the replication of bovine viral diarrhea virus
title_sort prostaglandin a(1) inhibits the replication of bovine viral diarrhea virus
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6175701/
https://www.ncbi.nlm.nih.gov/pubmed/29544983
http://dx.doi.org/10.1016/j.bjm.2017.12.010
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