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C(16)-ceramide is a natural regulatory ligand of p53 in cellular stress response

Ceramides are important participants of signal transduction, regulating fundamental cellular processes. Here we report the mechanism for activation of p53 tumor suppressor by C(16)-ceramide. C(16)-ceramide tightly binds within the p53 DNA-binding domain (K(d) ~ 60 nM), in close vicinity to the Box V...

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Detalles Bibliográficos
Autores principales:	Fekry, Baharan, Jeffries, Kristen A., Esmaeilniakooshkghazi, Amin, Szulc, Zdzislaw M., Knagge, Kevin J., Kirchner, David R., Horita, David A., Krupenko, Sergey A., Krupenko, Natalia I.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6175828/ https://www.ncbi.nlm.nih.gov/pubmed/30297838 http://dx.doi.org/10.1038/s41467-018-06650-y

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