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Mammographic Density Distribution of Healthy Taiwanese Women and its Naturally Decreasing Trend with Age
We analysed typical mammographic density (MD) distributions of healthy Taiwanese women to augment existing knowledge, clarify cancer risks, and focus public health efforts. From January 2011 to December 2015, 88,193 digital mammograms were obtained from 69,330 healthy Taiwanese women (average, 1.27...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6175874/ https://www.ncbi.nlm.nih.gov/pubmed/30297784 http://dx.doi.org/10.1038/s41598-018-32923-z |
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author | Shia, Wei-Chung Wu, Hwa-Koon Huang, Yu-Len Lin, Li-Sheng Chen, Dar-Ren |
author_facet | Shia, Wei-Chung Wu, Hwa-Koon Huang, Yu-Len Lin, Li-Sheng Chen, Dar-Ren |
author_sort | Shia, Wei-Chung |
collection | PubMed |
description | We analysed typical mammographic density (MD) distributions of healthy Taiwanese women to augment existing knowledge, clarify cancer risks, and focus public health efforts. From January 2011 to December 2015, 88,193 digital mammograms were obtained from 69,330 healthy Taiwanese women (average, 1.27 mammograms each). MD measurements included dense volume (DV) and volumetric density percentage (VPD) and were quantified by fully automated volumetric density estimation and Box-Cox normalization. Prediction of the declining MD trend was estimated using curve fitting and a rational model. Normalized DV and VPD Lowess curves demonstrated similar but non-identical distributions. In high-density grade participants, the VPD increased from 12.45% in the 35–39-year group to 13.29% in the 65–69-year group but only from 5.21% to 8.47% in low-density participants. Regarding the decreased cumulative VPD percentage, the mean MD declined from 12.79% to 19.31% in the 45–50-year group versus the 50–55-year group. The large MD decrease in the fifth decade in this present study was similar to previous observations of Western women. Obtaining an MD distribution model with age improves the understanding of breast density trends and age variations and provides a reference for future studies on associations between MD and cancer risk. |
format | Online Article Text |
id | pubmed-6175874 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-61758742018-10-12 Mammographic Density Distribution of Healthy Taiwanese Women and its Naturally Decreasing Trend with Age Shia, Wei-Chung Wu, Hwa-Koon Huang, Yu-Len Lin, Li-Sheng Chen, Dar-Ren Sci Rep Article We analysed typical mammographic density (MD) distributions of healthy Taiwanese women to augment existing knowledge, clarify cancer risks, and focus public health efforts. From January 2011 to December 2015, 88,193 digital mammograms were obtained from 69,330 healthy Taiwanese women (average, 1.27 mammograms each). MD measurements included dense volume (DV) and volumetric density percentage (VPD) and were quantified by fully automated volumetric density estimation and Box-Cox normalization. Prediction of the declining MD trend was estimated using curve fitting and a rational model. Normalized DV and VPD Lowess curves demonstrated similar but non-identical distributions. In high-density grade participants, the VPD increased from 12.45% in the 35–39-year group to 13.29% in the 65–69-year group but only from 5.21% to 8.47% in low-density participants. Regarding the decreased cumulative VPD percentage, the mean MD declined from 12.79% to 19.31% in the 45–50-year group versus the 50–55-year group. The large MD decrease in the fifth decade in this present study was similar to previous observations of Western women. Obtaining an MD distribution model with age improves the understanding of breast density trends and age variations and provides a reference for future studies on associations between MD and cancer risk. Nature Publishing Group UK 2018-10-08 /pmc/articles/PMC6175874/ /pubmed/30297784 http://dx.doi.org/10.1038/s41598-018-32923-z Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Shia, Wei-Chung Wu, Hwa-Koon Huang, Yu-Len Lin, Li-Sheng Chen, Dar-Ren Mammographic Density Distribution of Healthy Taiwanese Women and its Naturally Decreasing Trend with Age |
title | Mammographic Density Distribution of Healthy Taiwanese Women and its Naturally Decreasing Trend with Age |
title_full | Mammographic Density Distribution of Healthy Taiwanese Women and its Naturally Decreasing Trend with Age |
title_fullStr | Mammographic Density Distribution of Healthy Taiwanese Women and its Naturally Decreasing Trend with Age |
title_full_unstemmed | Mammographic Density Distribution of Healthy Taiwanese Women and its Naturally Decreasing Trend with Age |
title_short | Mammographic Density Distribution of Healthy Taiwanese Women and its Naturally Decreasing Trend with Age |
title_sort | mammographic density distribution of healthy taiwanese women and its naturally decreasing trend with age |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6175874/ https://www.ncbi.nlm.nih.gov/pubmed/30297784 http://dx.doi.org/10.1038/s41598-018-32923-z |
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