ROS-induced R loops trigger a transcription-coupled but BRCA1/2-independent homologous recombination pathway through CSB

Actively transcribed regions of the genome are protected by transcription-coupled DNA repair mechanisms, including transcription-coupled homologous recombination (TC-HR). Here we used reactive oxygen species (ROS) to induce and characterize TC-HR at a transcribed locus in human cells. As canonical H...

Descripción completa

Detalles Bibliográficos
Autores principales: Teng, Yaqun, Yadav, Tribhuwan, Duan, Meihan, Tan, Jun, Xiang, Yufei, Gao, Boya, Xu, Jianquan, Liang, Zhuobin, Liu, Yang, Nakajima, Satoshi, Shi, Yi, Levine, Arthur S., Zou, Lee, Lan, Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6175878/
https://www.ncbi.nlm.nih.gov/pubmed/30297739
http://dx.doi.org/10.1038/s41467-018-06586-3

Ejemplares similares

Ejemplares similares