SWI/SNF catalytic subunits’ switch drives resistance to EZH2 inhibitors in ARID1A-mutated cells

Inactivation of the subunits of SWI/SNF complex such as ARID1A is synthetically lethal with inhibition of EZH2 activity. However, mechanisms of de novo resistance to EZH2 inhibitors in cancers with inactivating SWI/SNF mutations are unknown. Here we show that the switch of the SWI/SNF catalytic subu...

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Detalles Bibliográficos
Autores principales: Wu, Shuai, Fatkhutdinov, Nail, Fukumoto, Takeshi, Bitler, Benjamin G., Park, Pyoung Hwa, Kossenkov, Andrew V., Trizzino, Marco, Tang, Hsin-Yao, Zhang, Lin, Gardini, Alessandro, Speicher, David W., Zhang, Rugang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6175882/
https://www.ncbi.nlm.nih.gov/pubmed/30297712
http://dx.doi.org/10.1038/s41467-018-06656-6

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