Rifamycin congeners kanglemycins are active against rifampicin-resistant bacteria via a distinct mechanism

Rifamycin antibiotics (Rifs) target bacterial RNA polymerases (RNAPs) and are widely used to treat infections including tuberculosis. The utility of these compounds is threatened by the increasing incidence of resistance (Rif(R)). As resistance mechanisms found in clinical settings may also occur in...

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Detalles Bibliográficos
Autores principales: Peek, James, Lilic, Mirjana, Montiel, Daniel, Milshteyn, Aleksandr, Woodworth, Ian, Biggins, John B., Ternei, Melinda A., Calle, Paula Y., Danziger, Michael, Warrier, Thulasi, Saito, Kohta, Braffman, Nathaniel, Fay, Allison, Glickman, Michael S., Darst, Seth A., Campbell, Elizabeth A., Brady, Sean F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6175910/
https://www.ncbi.nlm.nih.gov/pubmed/30297823
http://dx.doi.org/10.1038/s41467-018-06587-2

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