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Electrophysiological evidence for abnormal glutamate-GABA association following psychosis onset
Previous studies have shown glutamatergic dysfunction and γ-aminobutyric acid (GABA)-ergic dysfunction in schizophrenia. Animal studies suggest that N-methyl-d-aspartate receptor (NMDAR) dysfunction and GABA-ergic dysfunction interact with each other and lead to alterations in excitatory/inhibitory...
Autores principales: | , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Nature Publishing Group UK
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6175929/ https://www.ncbi.nlm.nih.gov/pubmed/30297786 http://dx.doi.org/10.1038/s41398-018-0261-0 |
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author | Koshiyama, Daisuke Kirihara, Kenji Tada, Mariko Nagai, Tatsuya Fujioka, Mao Ichikawa, Eriko Ohta, Kazusa Tani, Motoko Tsuchiya, Maiko Kanehara, Akiko Morita, Kentaro Sawada, Kingo Matsuoka, Jun Satomura, Yoshihiro Koike, Shinsuke Suga, Motomu Araki, Tsuyoshi Kasai, Kiyoto |
author_facet | Koshiyama, Daisuke Kirihara, Kenji Tada, Mariko Nagai, Tatsuya Fujioka, Mao Ichikawa, Eriko Ohta, Kazusa Tani, Motoko Tsuchiya, Maiko Kanehara, Akiko Morita, Kentaro Sawada, Kingo Matsuoka, Jun Satomura, Yoshihiro Koike, Shinsuke Suga, Motomu Araki, Tsuyoshi Kasai, Kiyoto |
author_sort | Koshiyama, Daisuke |
collection | PubMed |
description | Previous studies have shown glutamatergic dysfunction and γ-aminobutyric acid (GABA)-ergic dysfunction in schizophrenia. Animal studies suggest that N-methyl-d-aspartate receptor (NMDAR) dysfunction and GABA-ergic dysfunction interact with each other and lead to alterations in excitatory/inhibitory balance. The NMDAR and GABAergic-interneuron functions may be indexed by mismatch negativity (MMN) and auditory steady-state gamma-band response (ASSR), respectively. However, no previous studies have tested the hypothesis of an abnormal association between MMN and gamma-band ASSR in the same patients to identify the in vivo evidence of NMDAR-GABA association during the early stages of psychosis. Participants were individuals with recent-onset schizophrenia (ROSZ; N = 21), ultra-high risk (UHR; N = 27), and healthy controls (HCs; N = 24). The MMN amplitude was significantly impaired in ROSZ (p = 0.001, d = 1.20) and UHR (p = 0.003, d = 1.01) compared with HCs. The intertrial phase coherence (ITC) index of gamma-band ASSR was significantly reduced in ROSZ compared with HCs (p < 0.001, d = –1.27) and UHR (p = 0.032, d = –0.75). The event-related spectral perturbation (ERSP) index of gamma-band ASSR was significantly smaller in ROSZ compared with HCs (p < 0.001, d = −1.21). The MMN amplitude was significantly correlated with the ITC in ROSZ (r = −0.69, p < 0.001). These findings provide the first in vivo evidence that an abnormal association of the electrophysiological indices of NMDAR and GABA dysfunctions may be present in recent-onset schizophrenia. |
format | Online Article Text |
id | pubmed-6175929 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-61759292018-10-09 Electrophysiological evidence for abnormal glutamate-GABA association following psychosis onset Koshiyama, Daisuke Kirihara, Kenji Tada, Mariko Nagai, Tatsuya Fujioka, Mao Ichikawa, Eriko Ohta, Kazusa Tani, Motoko Tsuchiya, Maiko Kanehara, Akiko Morita, Kentaro Sawada, Kingo Matsuoka, Jun Satomura, Yoshihiro Koike, Shinsuke Suga, Motomu Araki, Tsuyoshi Kasai, Kiyoto Transl Psychiatry Article Previous studies have shown glutamatergic dysfunction and γ-aminobutyric acid (GABA)-ergic dysfunction in schizophrenia. Animal studies suggest that N-methyl-d-aspartate receptor (NMDAR) dysfunction and GABA-ergic dysfunction interact with each other and lead to alterations in excitatory/inhibitory balance. The NMDAR and GABAergic-interneuron functions may be indexed by mismatch negativity (MMN) and auditory steady-state gamma-band response (ASSR), respectively. However, no previous studies have tested the hypothesis of an abnormal association between MMN and gamma-band ASSR in the same patients to identify the in vivo evidence of NMDAR-GABA association during the early stages of psychosis. Participants were individuals with recent-onset schizophrenia (ROSZ; N = 21), ultra-high risk (UHR; N = 27), and healthy controls (HCs; N = 24). The MMN amplitude was significantly impaired in ROSZ (p = 0.001, d = 1.20) and UHR (p = 0.003, d = 1.01) compared with HCs. The intertrial phase coherence (ITC) index of gamma-band ASSR was significantly reduced in ROSZ compared with HCs (p < 0.001, d = –1.27) and UHR (p = 0.032, d = –0.75). The event-related spectral perturbation (ERSP) index of gamma-band ASSR was significantly smaller in ROSZ compared with HCs (p < 0.001, d = −1.21). The MMN amplitude was significantly correlated with the ITC in ROSZ (r = −0.69, p < 0.001). These findings provide the first in vivo evidence that an abnormal association of the electrophysiological indices of NMDAR and GABA dysfunctions may be present in recent-onset schizophrenia. Nature Publishing Group UK 2018-10-08 /pmc/articles/PMC6175929/ /pubmed/30297786 http://dx.doi.org/10.1038/s41398-018-0261-0 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Koshiyama, Daisuke Kirihara, Kenji Tada, Mariko Nagai, Tatsuya Fujioka, Mao Ichikawa, Eriko Ohta, Kazusa Tani, Motoko Tsuchiya, Maiko Kanehara, Akiko Morita, Kentaro Sawada, Kingo Matsuoka, Jun Satomura, Yoshihiro Koike, Shinsuke Suga, Motomu Araki, Tsuyoshi Kasai, Kiyoto Electrophysiological evidence for abnormal glutamate-GABA association following psychosis onset |
title | Electrophysiological evidence for abnormal glutamate-GABA association following psychosis onset |
title_full | Electrophysiological evidence for abnormal glutamate-GABA association following psychosis onset |
title_fullStr | Electrophysiological evidence for abnormal glutamate-GABA association following psychosis onset |
title_full_unstemmed | Electrophysiological evidence for abnormal glutamate-GABA association following psychosis onset |
title_short | Electrophysiological evidence for abnormal glutamate-GABA association following psychosis onset |
title_sort | electrophysiological evidence for abnormal glutamate-gaba association following psychosis onset |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6175929/ https://www.ncbi.nlm.nih.gov/pubmed/30297786 http://dx.doi.org/10.1038/s41398-018-0261-0 |
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