Hydrophobic alkyl chains substituted to the 8-position of cyclic nucleotides enhance activation of CNG and HCN channels by an intricate enthalpy - entropy compensation

Cyclic nucleotide-gated (CNG) and hyperpolarization-activated cyclic nucleotide-gated (HCN) channels are tetrameric non-specific cation channels in the plasma membrane that are activated by either cAMP or cGMP binding to specific binding domains incorporated in each subunit. Typical apparent affinit...

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Detalles Bibliográficos
Autores principales: Otte, Maik, Schweinitz, Andrea, Bonus, Michele, Enke, Uta, Schumann, Christina, Gohlke, Holger, Benndorf, Klaus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6175941/
https://www.ncbi.nlm.nih.gov/pubmed/30297855
http://dx.doi.org/10.1038/s41598-018-33050-5

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