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Multiple intrasyntenic rearrangements and rapid speciation in voles
Remarkably stable genomic chromosome elements (evolutionary conserved segments or syntenies) are the basis of large-scale chromosome architecture in vertebrate species. However, these syntenic elements harbour evolutionary important changes through intrachromosomal rearrangements such as inversions...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6175948/ https://www.ncbi.nlm.nih.gov/pubmed/30297915 http://dx.doi.org/10.1038/s41598-018-33300-6 |
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author | Romanenko, Svetlana A. Serdyukova, Natalya A. Perelman, Polina L. Trifonov, Vladimir A. Golenishchev, Feodor N. Bulatova, Nina Sh. Stanyon, Roscoe Graphodatsky, Alexander S. |
author_facet | Romanenko, Svetlana A. Serdyukova, Natalya A. Perelman, Polina L. Trifonov, Vladimir A. Golenishchev, Feodor N. Bulatova, Nina Sh. Stanyon, Roscoe Graphodatsky, Alexander S. |
author_sort | Romanenko, Svetlana A. |
collection | PubMed |
description | Remarkably stable genomic chromosome elements (evolutionary conserved segments or syntenies) are the basis of large-scale chromosome architecture in vertebrate species. However, these syntenic elements harbour evolutionary important changes through intrachromosomal rearrangements such as inversions and centromere repositioning. Here, using FISH with a set of 20 region-specific probes on a wide array of 28 species, we analyzed evolution of three conserved syntenic regions of the Arvicolinae ancestral karyotype. Inside these syntenies we uncovered multiple, previously cryptic intrachromosomal rearrangements. Although in each of the three conserved blocks we found inversions and centromere repositions, the blocks experienced different types of rearrangements. In two syntenies centromere repositioning predominated, while in the third region, paracentric inversions were more frequent, whereas pericentric inversions were not detected. We found that some of the intrachromosomal rearrangements, mainly paracentric inversions, were synapomorphic for whole arvicoline genera or tribes: genera Alexandromys and Microtus, tribes Ellobini and Myodini. We hypothesize that intrachromosomal rearrangements within conserved syntenic blocks are a major evolutionary force modulating genome architecture in species-rich and rapidly-evolving rodent taxa. Inversions and centromere repositioning may impact speciation and provide a potential link between genome evolution, speciation, and biogeography. |
format | Online Article Text |
id | pubmed-6175948 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-61759482018-10-12 Multiple intrasyntenic rearrangements and rapid speciation in voles Romanenko, Svetlana A. Serdyukova, Natalya A. Perelman, Polina L. Trifonov, Vladimir A. Golenishchev, Feodor N. Bulatova, Nina Sh. Stanyon, Roscoe Graphodatsky, Alexander S. Sci Rep Article Remarkably stable genomic chromosome elements (evolutionary conserved segments or syntenies) are the basis of large-scale chromosome architecture in vertebrate species. However, these syntenic elements harbour evolutionary important changes through intrachromosomal rearrangements such as inversions and centromere repositioning. Here, using FISH with a set of 20 region-specific probes on a wide array of 28 species, we analyzed evolution of three conserved syntenic regions of the Arvicolinae ancestral karyotype. Inside these syntenies we uncovered multiple, previously cryptic intrachromosomal rearrangements. Although in each of the three conserved blocks we found inversions and centromere repositions, the blocks experienced different types of rearrangements. In two syntenies centromere repositioning predominated, while in the third region, paracentric inversions were more frequent, whereas pericentric inversions were not detected. We found that some of the intrachromosomal rearrangements, mainly paracentric inversions, were synapomorphic for whole arvicoline genera or tribes: genera Alexandromys and Microtus, tribes Ellobini and Myodini. We hypothesize that intrachromosomal rearrangements within conserved syntenic blocks are a major evolutionary force modulating genome architecture in species-rich and rapidly-evolving rodent taxa. Inversions and centromere repositioning may impact speciation and provide a potential link between genome evolution, speciation, and biogeography. Nature Publishing Group UK 2018-10-08 /pmc/articles/PMC6175948/ /pubmed/30297915 http://dx.doi.org/10.1038/s41598-018-33300-6 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Romanenko, Svetlana A. Serdyukova, Natalya A. Perelman, Polina L. Trifonov, Vladimir A. Golenishchev, Feodor N. Bulatova, Nina Sh. Stanyon, Roscoe Graphodatsky, Alexander S. Multiple intrasyntenic rearrangements and rapid speciation in voles |
title | Multiple intrasyntenic rearrangements and rapid speciation in voles |
title_full | Multiple intrasyntenic rearrangements and rapid speciation in voles |
title_fullStr | Multiple intrasyntenic rearrangements and rapid speciation in voles |
title_full_unstemmed | Multiple intrasyntenic rearrangements and rapid speciation in voles |
title_short | Multiple intrasyntenic rearrangements and rapid speciation in voles |
title_sort | multiple intrasyntenic rearrangements and rapid speciation in voles |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6175948/ https://www.ncbi.nlm.nih.gov/pubmed/30297915 http://dx.doi.org/10.1038/s41598-018-33300-6 |
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