Direct protein-lipid interactions shape the conformational landscape of secondary transporters

Secondary transporters undergo structural rearrangements to catalyze substrate translocation across the cell membrane – yet how such conformational changes happen within a lipid environment remains poorly understood. Here, we combine hydrogen-deuterium exchange mass spectrometry (HDX-MS) with molecu...

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Detalles Bibliográficos
Autores principales: Martens, Chloe, Shekhar, Mrinal, Borysik, Antoni J., Lau, Andy M., Reading, Eamonn, Tajkhorshid, Emad, Booth, Paula J., Politis, Argyris
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6175955/
https://www.ncbi.nlm.nih.gov/pubmed/30297844
http://dx.doi.org/10.1038/s41467-018-06704-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6175955/
https://www.ncbi.nlm.nih.gov/pubmed/30297844
http://dx.doi.org/10.1038/s41467-018-06704-1

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