Application of spin-crossover water soluble nanoparticles for use as MRI contrast agents

Water soluble spin-crossover (SCO) iron(II) nanoparticles (NPs) were synthesized by the polyethylene glycol (PEG) coating of [Fe(Htrz)(3-3×)(NH(2)trz)(3×)](BF(4))(2) (x = 0, 0.1, 0.5 and 1). The NPs with x = 0.1 show gradual SCO behavior over 280–330 K in water. The relaxation times, T1 and T2, were...

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Detalles Bibliográficos
Autores principales: Tsukiashi, Asami, Min, Kil Sik, Kitayama, Hikaru, Terasawa, Hiroaki, Yoshinaga, Sosuke, Takeda, Mitsuhiro, Lindoy, Leonard F., Hayami, Shinya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6175957/
https://www.ncbi.nlm.nih.gov/pubmed/30297794
http://dx.doi.org/10.1038/s41598-018-33362-6
Descripción
Sumario:Water soluble spin-crossover (SCO) iron(II) nanoparticles (NPs) were synthesized by the polyethylene glycol (PEG) coating of [Fe(Htrz)(3-3×)(NH(2)trz)(3×)](BF(4))(2) (x = 0, 0.1, 0.5 and 1). The NPs with x = 0.1 show gradual SCO behavior over 280–330 K in water. The relaxation times, T1 and T2, were determined and the thermally-responsive T2 values making these NPs a candidate for use as a MRI contrast agent.

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