Application of spin-crossover water soluble nanoparticles for use as MRI contrast agents

Water soluble spin-crossover (SCO) iron(II) nanoparticles (NPs) were synthesized by the polyethylene glycol (PEG) coating of [Fe(Htrz)(3-3×)(NH(2)trz)(3×)](BF(4))(2) (x = 0, 0.1, 0.5 and 1). The NPs with x = 0.1 show gradual SCO behavior over 280–330 K in water. The relaxation times, T1 and T2, were...

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Autores principales: Tsukiashi, Asami, Min, Kil Sik, Kitayama, Hikaru, Terasawa, Hiroaki, Yoshinaga, Sosuke, Takeda, Mitsuhiro, Lindoy, Leonard F., Hayami, Shinya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6175957/
https://www.ncbi.nlm.nih.gov/pubmed/30297794
http://dx.doi.org/10.1038/s41598-018-33362-6
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author Tsukiashi, Asami
Min, Kil Sik
Kitayama, Hikaru
Terasawa, Hiroaki
Yoshinaga, Sosuke
Takeda, Mitsuhiro
Lindoy, Leonard F.
Hayami, Shinya
author_facet Tsukiashi, Asami
Min, Kil Sik
Kitayama, Hikaru
Terasawa, Hiroaki
Yoshinaga, Sosuke
Takeda, Mitsuhiro
Lindoy, Leonard F.
Hayami, Shinya
author_sort Tsukiashi, Asami
collection PubMed
description Water soluble spin-crossover (SCO) iron(II) nanoparticles (NPs) were synthesized by the polyethylene glycol (PEG) coating of [Fe(Htrz)(3-3×)(NH(2)trz)(3×)](BF(4))(2) (x = 0, 0.1, 0.5 and 1). The NPs with x = 0.1 show gradual SCO behavior over 280–330 K in water. The relaxation times, T1 and T2, were determined and the thermally-responsive T2 values making these NPs a candidate for use as a MRI contrast agent.
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spelling pubmed-61759572018-10-12 Application of spin-crossover water soluble nanoparticles for use as MRI contrast agents Tsukiashi, Asami Min, Kil Sik Kitayama, Hikaru Terasawa, Hiroaki Yoshinaga, Sosuke Takeda, Mitsuhiro Lindoy, Leonard F. Hayami, Shinya Sci Rep Article Water soluble spin-crossover (SCO) iron(II) nanoparticles (NPs) were synthesized by the polyethylene glycol (PEG) coating of [Fe(Htrz)(3-3×)(NH(2)trz)(3×)](BF(4))(2) (x = 0, 0.1, 0.5 and 1). The NPs with x = 0.1 show gradual SCO behavior over 280–330 K in water. The relaxation times, T1 and T2, were determined and the thermally-responsive T2 values making these NPs a candidate for use as a MRI contrast agent. Nature Publishing Group UK 2018-10-08 /pmc/articles/PMC6175957/ /pubmed/30297794 http://dx.doi.org/10.1038/s41598-018-33362-6 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Tsukiashi, Asami
Min, Kil Sik
Kitayama, Hikaru
Terasawa, Hiroaki
Yoshinaga, Sosuke
Takeda, Mitsuhiro
Lindoy, Leonard F.
Hayami, Shinya
Application of spin-crossover water soluble nanoparticles for use as MRI contrast agents
title Application of spin-crossover water soluble nanoparticles for use as MRI contrast agents
title_full Application of spin-crossover water soluble nanoparticles for use as MRI contrast agents
title_fullStr Application of spin-crossover water soluble nanoparticles for use as MRI contrast agents
title_full_unstemmed Application of spin-crossover water soluble nanoparticles for use as MRI contrast agents
title_short Application of spin-crossover water soluble nanoparticles for use as MRI contrast agents
title_sort application of spin-crossover water soluble nanoparticles for use as mri contrast agents
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6175957/
https://www.ncbi.nlm.nih.gov/pubmed/30297794
http://dx.doi.org/10.1038/s41598-018-33362-6
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